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Literature summary for 4.6.1.1 extracted from

  • Kloster, M.M.; Hafte, T.T.; Moltzau, L.R.; Naderi, E.H.; Dahle, M.K.; Skalhegg, B.S.; Gaudernack, G.; Levy, F.O.; Naderi, S.; Blomhoff, H.K.
    EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase (2008), Cell. Signal., 20, 1169-1178.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin forskolin-sensitive isozymes Homo sapiens
GTPgammaS a nonhydrolysable GTP analogue, increases AC activity Homo sapiens
isoproterenol
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information Epstein Barr virus infection prevents activation of the cAMP/PKA pathway, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Homo sapiens
NaF activates Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens the enzyme is involved in cAMP signaling and cAMP/PKA-mediated growth inhibition 3',5'-cyclic-AMP + diphosphate cAMP activates protein kinase A ?
additional information Homo sapiens Epstein Barr virus infection of B-lymphocyte renders the cells resistent against to cAMP/PKA-mediated growth inhibition, and the infection abolishes enzyme activation by forskolin, NaF, and G proteins, and the ability of forskolin to inhibit camptothecin-induced apoptosis, and it abolishes the inhibitory effect of forskolin on apoptosis induced by S phase-specific cytotoxic drugs, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte forskolin-insensitive AC isoforms in various B cell populations Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the enzyme is involved in cAMP signaling and cAMP/PKA-mediated growth inhibition Homo sapiens 3',5'-cyclic-AMP + diphosphate cAMP activates protein kinase A ?
additional information Epstein Barr virus infection of B-lymphocyte renders the cells resistent against to cAMP/PKA-mediated growth inhibition, and the infection abolishes enzyme activation by forskolin, NaF, and G proteins, and the ability of forskolin to inhibit camptothecin-induced apoptosis, and it abolishes the inhibitory effect of forskolin on apoptosis induced by S phase-specific cytotoxic drugs, overview Homo sapiens ?
-
 ?