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Literature summary for 4.6.1.1 extracted from

  • Xu, X.L.; Lee, R.T.; Fang, H.M.; Wang, Y.M.; Li, R.; Zou, H.; Zhu, Y.; Wang, Y.
    Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p (2008), Cell Host Microbe, 4, 28-39.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
1,6-anhydro-MurNAc-L-Ala-D-Glu
-
 Candida albicans
bacterial peptidoglycan direct activation of Cyr1p Candida albicans
CO2 synergistic effects of synthetic muramyl dipeptides and CO2 Candida albicans
additional information the upstream regulator of Cyr1p, RAS1, is required for optimal response of the organism to synthetic muramyl dipeptides Candida albicans
Mur-L-Ala-D-Glu
-
 Candida albicans
MurNAc-L-Ala-D-Glu
-
 Candida albicans
synthetic muramyl dipeptides subunits of bacterial peptidoglycan, strong activation of the enzyme and of hyphal growth, NMR analysis, overview. The LRR domain of Cyr1p is required as bindin gsite for Candida albicans response to the peptides, overview. Synergistic effects of synthetic muramyl dipeptides and CO2 Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information construction of a mutant strain expressing a version of Cyr1p with an N-terminal His-Flag-Myc tag under the control of the MET3 promoter Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Candida albicans Cyr1p is a key component of the cAMP/PKA-signaling pathway that controls diverse infection-related traits, including hyphal morphogenesis 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Candida albicans Ras1p and Cyr1p work as a complex that constitutes part of a sensor/effector machinery, and their interaction ensures proper protein folding for optimal ligand sensing and/or subsequent allosteric activation of the catalytic domain, without Ras1p the system functions partially, thereby requiring strong inducing signals to activate downstream events for hyphal growth, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypha
-
 Candida albicans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Candida albicans 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Cyr1p is a key component of the cAMP/PKA-signaling pathway that controls diverse infection-related traits, including hyphal morphogenesis Candida albicans 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Ras1p and Cyr1p work as a complex that constitutes part of a sensor/effector machinery, and their interaction ensures proper protein folding for optimal ligand sensing and/or subsequent allosteric activation of the catalytic domain, without Ras1p the system functions partially, thereby requiring strong inducing signals to activate downstream events for hyphal growth, overview Candida albicans ?
-
 ?

Synonyms

Synonyms Comment Organism
Cyr1p
-
 Candida albicans