Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Koukoulitsa, C.; Zervou, M.; Demetzos, C.; Mavromoustakos, T.
    Comparative docking studies of labdane-type diterpenes with forskolin at the active site of adenylyl cyclase (2008), Bioorg. Med. Chem., 16, 8237-8243.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
forskolin structure-activity relationship Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1alpha,9alpha-dihydroxy-labd-13(E)-ene-8a,15-diol a derivative of each of the two stereoisomers of labd-13(E)-ene-8a,15-diol, overview Homo sapiens
1alpha-hydroxy-labd-13(E)-ene-8a,15-diol a derivative of each of the two stereoisomers of labd-13(E)-ene-8a,15-diol, overview Homo sapiens
labd-13(E)-ene-8a,15-diol isolated from the resin Ladano of the plant Cistus creticus subsp. creticus that grows in the island of Crete, Greece. Docking calculations of the two stereoisomers of the compound and derivatives to the enzyme at the forskolin binding site, overview Homo sapiens
additional information structure-activity relationship Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens
-
3',5'-cyclic-AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
?