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Literature summary for 4.6.1.1 extracted from

  • Sinha, S.C.; Sprang, S.R.
    Structure, mechanism, regulation and evolution of class III nucleotidyl cyclases (2007), Rev. Physiol. Biochem. Pharmacol., 157, 105-140.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
bicarbonate
-
 Arthrospira platensis
forskolin
-
 Rattus norvegicus
Galphas stimulates the VC1-IIC2 heterodimer Rattus norvegicus
Galphas stimulates the VC1-IIC2 heterodimer Canis lupus familiaris
additional information is activated by different host cell factors and is inactive until injected into the host cell Pseudomonas aeruginosa
additional information is activated by different host cell factors and is inactive until injected into the host cell Bordetella pertussis
additional information is activated by different host cell factors and is inactive until injected into the host cell Bacillus anthracis
additional information Rv1264 is a pH-regulated enzyme Mycobacterium tuberculosis

Application

Application Comment Organism
additional information contains a GGDEF domain Caulobacter vibrioides
additional information is an exotoxin Pseudomonas aeruginosa
additional information is an exotoxin Bordetella pertussis
additional information is an exotoxin Bacillus anthracis
additional information restores adenylate cyclase activity in Escherichia coli knockout mutants Sinorhizobium meliloti
additional information restores adenylate cyclase activity in Escherichia coli knockout mutants Rhizobium etli
additional information restores adenylate cyclase activity in Escherichia coli knockout mutants Aeromonas hydrophila
additional information restores adenylate cyclase activity in Escherichia coli knockout mutants Prevotella ruminicola
additional information Rv1264 plays a role in mycobacterial survival in the acidic environment of the pahgolysosome Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
Rv1264 crystallized at neutral and acidic pH, CHD activity regulated by dramatic conformational changes Mycobacterium tuberculosis
VC1-IIC2 heterodimer in complex with ATP analogs Rattus norvegicus
VC1-IIC2 heterodimer in complex with ATP analogs Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
AMPCPP
-
 Arthrospira platensis
catechol noncompetetive inhibitor Arthrospira platensis
MANT-GTP inhibits the VC1-IIC2 heterodimer Canis lupus familiaris
MANT-GTP inhibits the VC1-IIC2 heterodimer Rattus norvegicus
additional information PleD is subject to tight feedback inhibition by the product c-diGMP Caulobacter vibrioides

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Arthrospira platensis
Mg2+
-
 Rattus norvegicus
Mg2+
-
 Canis lupus familiaris
Mg2+
-
 Arthrospira platensis
Mn2+
-
 Rattus norvegicus
Mn2+
-
 Canis lupus familiaris
Mn2+ Rv1900c Mycobacterium tuberculosis
additional information no metals bound in the structure of the c-diGMP-bound PleD complex Caulobacter vibrioides

Organism

Organism UniProt Comment Textmining
Aeromonas hydrophila
-
-
-
Arthrospira platensis
-
-
-
Bacillus anthracis
-
-
-
Bordetella pertussis
-
-
-
Canis lupus familiaris
-
-
-
Caulobacter vibrioides
-
-
-
Escherichia sp.
-
-
-
Haemophilus sp.
-
-
-
Mycobacterium tuberculosis
-
-
-
Prevotella ruminicola
-
-
-
Pseudomonas aeruginosa
-
-
-
Pseudomonas sp.
-
-
-
Rattus norvegicus
-
-
-
Rhizobium etli
-
-
-
Sinorhizobium meliloti
-
-
-
Trypanosoma brucei
-
-
-
Vibrio parahaemolyticus
-
-
-
Yersinia pestis
-
-
-
Yersinia sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 GTP
-
 Caulobacter vibrioides c-diGMP + 2 diphosphate
-
 ?
ATP
-
 Sinorhizobium meliloti 3',5'-cAMP + diphosphate
-
 ?
ATP
-
 Rattus norvegicus 3',5'-cAMP + diphosphate
-
 ?
ATP
-
 Canis lupus familiaris 3',5'-cAMP + diphosphate
-
 ?
ATP
-
 Arthrospira platensis 3',5'-cAMP + diphosphate
-
 ?
ATP Rv1900, C-terminal CHD can use both ATP and GTP as substrate but has a 14fold preference for ATP Mycobacterium tuberculosis 3',5'-cAMP + diphosphate
-
 ?
GTP Rv1900 Mycobacterium tuberculosis ?
-
 ?
GTP
-
 Sinorhizobium meliloti 3',5'-cGMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Caulobacter vibrioides
heterodimer
-
 Rattus norvegicus
homodimer
-
 Arthrospira platensis
homodimer Rv1900c and Rv1264 Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
class I AC
-
 Pseudomonas sp.
class I AC
-
 Yersinia sp.
class I AC
-
 Escherichia sp.
class I AC
-
 Haemophilus sp.
class II AC
-
 Pseudomonas aeruginosa
class II AC
-
 Bordetella pertussis
class II AC
-
 Bacillus anthracis
class III AC
-
 Rattus norvegicus
class III AC
-
 Trypanosoma brucei
class III AC
-
 Canis lupus familiaris
class III AC
-
 Mycobacterium tuberculosis
class III AC
-
 Caulobacter vibrioides
class III AC
-
 Arthrospira platensis
class IV AC
-
 Aeromonas hydrophila
class IV AC
-
 Yersinia pestis
class IV AC
-
 Vibrio parahaemolyticus
class V AC
-
 Prevotella ruminicola
class VI AC
-
 Rhizobium etli
Cya1
-
 Sinorhizobium meliloti
CyaA
-
 Bordetella pertussis
cyaC
-
 Arthrospira platensis
Edema factor
-
 Bacillus anthracis
GRESAG 4.1
-
 Trypanosoma brucei
GRESAG 4.3
-
 Trypanosoma brucei
IIC2
-
 Rattus norvegicus
PleD
-
 Caulobacter vibrioides
Rv1264
-
 Mycobacterium tuberculosis
Rv1625c
-
 Mycobacterium tuberculosis
Rv1900c
-
 Mycobacterium tuberculosis
type II AC
-
 Rattus norvegicus
type V AC
-
 Canis lupus familiaris
VC1
-
 Canis lupus familiaris