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Literature summary for 4.6.1.1 extracted from

  • Watts, V.J.
    Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection (2007), Mol. Interv., 7, 70-73.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin stimulates AC1 and AC8 in a Ca2+-dependent manner Mus musculus
Calmodulin stimulates AC8 in a Ca2+-dependent manner Rattus norvegicus
forskolin
-
 Mus musculus

Application

Application Comment Organism
medicine AC1 and AC8 involved in long-term memory and in N-methyl-D-aspartate-dependent long-term potentiation, AC1 and AC8 are not required for acute pain response. AC1 is the major Ca2+ sensor for N-methyl-D-aspartate receptor activation and excitotoxicity Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mice deficient in AC1, are resistant to glutamate-induced neuronal toxicity, double knock-out AC1 and AC8 mice, show long lasting long-term potentiation and memory deficits that are greater in animals lacking both AC1 and AC8, when compared to animals deficient in only a single isoform. Behavioral responses to inflammatory stimuli that appear to involve N-methyl-D-aspartate receptor pathways are markedly reduced in double knockouts and AC1-/- mice. AC1-/- mice are resistant to glutamate-induced neuronal toxicity Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required by AC1 and AC8, AC1 is sensitive to lower concentrations of Ca2+ and shows a greater synergistic response to Ca2+ and Galphas than does AC8 Mus musculus
Ca2+ required by AC8 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus AC1 and AC8 highly expressed Mus musculus
-
hippocampus AC8 highly expressed Rattus norvegicus
-
additional information cortical neuron Mus musculus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Mus musculus
AC8
-
 Mus musculus
AC8
-
 Rattus norvegicus
adenylyl cyclase type 1
-
 Mus musculus
type VIII adenylyl cyclase
-
 Rattus norvegicus