Literature summary for 4.6.1.1 extracted from

Willoughby, D.; Cooper, D.M.
Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP (2006), J. Cell Sci., 119, 828-836.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
Carbachol	carbachol-induced capacitative Ca2+ entry clearly stimulates AC8-mediated cAMP production at the single-cell level	Homo sapiens
isoprenaline	-	Homo sapiens
additional information	prior activation of AC8 is not strictly necessary to observe Ca2+-driven cAMP dynamics. Nevertheless, amplitude of the transients is enhanced when AC8 is stimulated	Homo sapiens
prostaglandin E1	-	Homo sapiens
thapsigargin	thapsigargin-induced capacitative Ca2+ entry clearly stimulates AC8-mediated cAMP production at the single-cell level	Homo sapiens

Application

Application	Comment	Organism
additional information	AC8 acts as a low-pass filter for high-frequency Ca2+ events, enhancing the regulatory options available to this signalling pathway	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	during artificial or agonist-induced Ca2+ oscillations, periodic changes in cAMP that depended upon Ca2+ stimulation of AC8 with subsequent PKA-mediated phosphodiesterase 4 activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Homo sapiens	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
AC8	-	Homo sapiens
type 8 adenylyl cyclase	-	Homo sapiens

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Release 2023.1 (January 2023)