Literature summary for 4.6.1.1 extracted from

Ortiz-Capisano, M.C.; Ortiz, P.A.; Harding, P.; Garvin, J.L.; Beierwaltes, W.H.
Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase (2007), Hypertension, 49, 162-169.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid	decreases intracellular calcium, stimulates adenylyl cyclase, increases intracellular cAMP content by 125% and basal renin by 182%	Mus musculus
forskolin	stimulates an 11fold increase in cAMP	Mus musculus
IBMX	increases basal renin release	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	-	Mus musculus
SQ 22536	adenylyl cyclase inhibitor, blocks both generation of cAMP and the release of renin, completely blocks 5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acidstimulated renin release and cAMP content	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	either/or both adenylyl cyclase types V and VI, colocalization of renin and adenylyl cyclase V/VI primarily on the granules	Mus musculus	5737	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
135000	-	either/or both adenylyl cyclase types V and VI, Western blotting	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C-57/B6 mice	-
Mus musculus C57/B6	-	C-57/B6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
heart	-	Mus musculus	-
additional information	juxtaglomerular cell	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Mus musculus	3',5'-cAMP + diphosphate	-	?
ATP	-	Mus musculus C57/B6	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
adenylyl cyclase type V	-	Mus musculus
adenylyl cyclase type VI	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)