Literature summary for 4.6.1.1 extracted from

Kolachala, V.L.; Obertone, T.S.; Wang, L.; Merlin, D.; Sitaraman, S.V.
Adenosine 2b receptor (A2bR) signals through adenylate cyclase (AC) 6 isoform in the intestinal epithelial cells (2006), Biochim. Biophys. Acta, 1760, 1102-1108.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
A2bR	-	Homo sapiens
A2bR	cAMP production induced only in cells transfected with A2bR	Cricetulus griseus

Application

Application	Comment	Organism
medicine	A2bR mediates signaling through AC-6 isoform, therapeutic implications for intestinal inflammation or diarrhea wherein A2bR is upregulated	Cricetulus griseus
medicine	A2bR mediates signaling through AC-6 isoform, therapeutic implications for intestinal inflammation or diarrhea wherein A2bR is upregulated	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of AC5 and AC6 in CHO cells co-transfected with A2bR in pCB6 expression vector along with AC5 and AC6 expression vectors	Cricetulus griseus

Inhibitors

Inhibitors	Comment	Organism	Structure
Carbachol	increases intracellular calcium, inhibits A2bR mediated increase in cAMP by 53%	Homo sapiens
PAPANANOATE	nitric oxide donor, completely abolishes A2bR mediated cAMP production	Homo sapiens
RNAi	AC5, AC6 and AC9 isoform-specific stealth RNAi, increases A2bR levels 12fold. AC5, AC6 and AC9 levels are inhibited by 60-80%. AC5 RNAi does not affect the levels of AC6 RNA and vice versa. cAMP production is inhibited in AC6 RNAi transfected cells but not in cells transfected with AC5 and AC9 RNAi, indicating that AC6 is associated with A2bR	Cricetulus griseus
S-nitroso-N-acetylpenicillamine	nitric oxide donor, inhibits A2bR mediated increase in cAMP by 64%	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO cell	expresses all nine adenylate cyclase isoforms	Cricetulus griseus	-
intestinal epithelium	-	Homo sapiens	-
T-84 cell	expresses all nine adenylate cyclase isoforms	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Cricetulus griseus	3',5'-cAMP + diphosphate	-	?
ATP	-	Homo sapiens	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
AC 1	-	Homo sapiens
AC 2	-	Homo sapiens
AC 3	-	Homo sapiens
AC 4	-	Homo sapiens
AC 5	-	Homo sapiens
AC 7	-	Homo sapiens
AC 8	-	Homo sapiens
AC 9	-	Homo sapiens
AC1	-	Cricetulus griseus
AC2	-	Cricetulus griseus
AC3	-	Cricetulus griseus
AC4	-	Cricetulus griseus
AC5	-	Cricetulus griseus
AC6	-	Cricetulus griseus
AC7	-	Cricetulus griseus
AC8	-	Cricetulus griseus
AC9	-	Cricetulus griseus
adenylate cyclase 6	-	Cricetulus griseus
adenylate cyclase 6	-	Homo sapiens

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Release 2023.1 (January 2023)