Literature summary for 4.6.1.1 extracted from

Sayner, S.; Stevens, T.
Soluble adenylate cyclase reveals the significance of compartmentalized cAMP on endothelial cell barrier function (2006), Biochem. Soc. Trans., 34, 492-494.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
forskolin	increases cAMP in both the plasma membrane and cytosolic compartments, induces inter-endothelial cell gaps in cells expressing the soluble adenylate cyclase, when the soluble chimaera is relocalized to the plasma membrane, the forskolin-stimulated adenylate cyclase activity does not induce gaps	synthetic construct

Application

Application	Comment	Organism
additional information	membrane transitions in cAMP strengthen the endothelial cell barrier, whereas the production of cAMP by soluble AC within the cytosol away from the membrane disrupts the endothelial cell barrier	synthetic construct

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	cytosolic AC activity overwhelms the barrier-protective effects of transmembrane AC activity in the formation of endothelial cells gaps	synthetic construct	5829	-
plasma membrane	-	synthetic construct	5886	-

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	synthetic construct	3',5'-cAMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
sACI/II	mammalian soluble AC chimaera	synthetic construct
soluble AC	-	synthetic construct
soluble adenylate cyclase	-	synthetic construct

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Release 2023.1 (January 2023)