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Literature summary for 4.6.1.1 extracted from

  • Alvarez-Curto, E.; Weening, K.E.; Schaap, P.
    Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG (2007), Biochem. J., 401, 309-316.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Protein Variants

Protein Variants Comment Organism
additional information aca-/rdeA- mutant cells with significant activity of ACB, which is not obscured by the presence of ACA, aca-/A15::ACG mutant cells, which express ACG Dictyostelium discoideum

Inhibitors

Inhibitors Comment Organism Structure
2',3'-O-isopropylidene adenosine specifically inhibits ACA in intact cells, without affecting ACB or ACG Dictyostelium discoideum
2',5'-dideoxyadenosine inhibits ACA, ACB and ACG in cell lysates, but not in intact cells Dictyostelium discoideum
2-amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
-
 Dictyostelium discoideum
9-tetrahydro-2'-furyladenine effective and specific inhibitor for ACA in cell lysates and intact cells Dictyostelium discoideum
alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile effective and specific inhibitor for ACG in cell lysates Dictyostelium discoideum
Caffeine inhibits cAMP accumulation by ACB and ACG. None among ACA, ACB and ACG is a direct target for the inhibitory effects of caffeine Dictyostelium discoideum
cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine inhibits ACA, ACB and ACG Dictyostelium discoideum
additional information 2-amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone does not inhibit ACG and has only a partial inhibitory effect on ACA and ACB Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression of ACA in NC4 cells Dictyostelium discoideum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Dictyostelium discoideum 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
ACA
-
 Dictyostelium discoideum
ACB
-
 Dictyostelium discoideum
ACG
-
 Dictyostelium discoideum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00578
-
 inhibition of ACB in cell lysates Dictyostelium discoideum 2-amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
0.016
-
 inhibition of ACG in cell lysates Dictyostelium discoideum alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile
0.0166
-
 inhibition of ACG in cell lysates Dictyostelium discoideum alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile
0.03
-
 inhibition of DcAMP-induced ACA activation in intact cells Dictyostelium discoideum 2',3'-O-isopropylidene adenosine
0.031
-
 inhibition of ACA in intact cells Dictyostelium discoideum 2',3'-O-isopropylidene adenosine
0.075
-
 inhibition of ACG in cell lysates Dictyostelium discoideum 2',5'-dideoxyadenosine
0.076
-
 inhibition of ACG in cell lysates Dictyostelium discoideum 2',5'-dideoxyadenosine
0.207
-
 inhibition of ACG in intact cells Dictyostelium discoideum Caffeine
0.274
-
 inhibition of ACA in cell lysates Dictyostelium discoideum 2',5'-dideoxyadenosine
0.274
-
 inhibition of ACA in cell lysates Dictyostelium discoideum 9-tetrahydro-2'-furyladenine
0.3
-
 inhibition of ACB in intact cells Dictyostelium discoideum Caffeine
0.329
-
 inhibition of ACA in cell lysates Dictyostelium discoideum cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine
0.336
-
 inhibition of ACB in cell lysates Dictyostelium discoideum 2',5'-dideoxyadenosine
0.361
-
 inhibition of ACA in intact cells Dictyostelium discoideum Caffeine
0.465
-
 inhibition of ACA in intact cells Dictyostelium discoideum 2',5'-dideoxyadenosine
0.497
-
 inhibition of ACB in cell lysates Dictyostelium discoideum cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine
0.602
-
 inhibition of ACG in intact cells Dictyostelium discoideum alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile
0.812
-
 inhibition of ACA in intact cells Dictyostelium discoideum 9-tetrahydro-2'-furyladenine
0.825
-
 inhibition of ACA in cell lysates Dictyostelium discoideum Caffeine
0.885
-
 inhibition of ACG in cell lysates Dictyostelium discoideum cis-N-(2-phenylcyclopentyl)azacyclotridec-1-en-2-amine
1.31
-
 inhibition of ACA in cell lysates Dictyostelium discoideum 2-amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
2.18
-
 inhibition of ACA in cell lysates Dictyostelium discoideum 2',3'-O-isopropylidene adenosine
11.19
-
 inhibition of ACA in intact cells Dictyostelium discoideum alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile
13.36
-
 inhibition of ACB in intact cells Dictyostelium discoideum alpha-cyano-(3,4,5-trihydroxy)cinnamonitrile