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Literature summary for 4.6.1.1 extracted from
- Adenylyl cyclase activity and its modulation in the gills of Mytilus galloprovincialis exposed to Cr6+ and Cu2+ (2006), Aquat. Toxicol., 76, 59-68.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxytryptamine | stimulation of enzyme activity up to 2.5fold | Mytilus galloprovincialis |  |
| forskolin | scarcely enhanced enzyme activity | Mytilus galloprovincialis | |
| guanosine 5'-(gamma-thio)triphosphate | stimulation of enzyme activity up to 3.5fold | Mytilus galloprovincialis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.82 | - |
ATP | pH 7.4, 22°C, 5mM Mg2+ | Mytilus galloprovincialis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mytilus galloprovincialis | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cr6+ | maximal enzyme stimulation at 10-8 M, inhibition at 10-5 M | Mytilus galloprovincialis | |
| Cu2+ | stimulation of enzyme activity at nanomolar concentrations, strong inhibition in the micromolar range | Mytilus galloprovincialis | |
| Mg2+ | in the absence of Mg2+ no activity observed | Mytilus galloprovincialis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | Mytilus galloprovincialis | - |
3',5'-cAMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mytilus galloprovincialis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gill | - |
Mytilus galloprovincialis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
basal activity 5.6 pmol cAMP /10 min /mg protein, pH7.4, 22°C, 5mM Mg2+ | Mytilus galloprovincialis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | - |
Mytilus galloprovincialis | 3',5'-cAMP + diphosphate | - |
? | |
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