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Literature summary for 4.6.1.1 extracted from
- Differential expression of membrane and soluble adenylyl cyclase isoforms in cytotrophoblast cells and syncytiotrophoblasts of human placenta (2003), Placenta, 24, 648-657.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Homo sapiens |  |
| G-protein | activation by betagamma subunits | Homo sapiens | |
| G-protein | betagamma subunit | Homo sapiens | |
| G-protein | betagamma subunits | Homo sapiens | |
| additional information | insensitive to either Ca2+ or betagamma subunits of G-proteins | Homo sapiens | |
| Protein kinase C | phosphorylation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | at low concentrations; inhibition by low concentrations | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulation | Homo sapiens | |
| Ca2+ | activation | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | Homo sapiens | - |
3',5'-cyclic AMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isoenzyme AC5 | - |
| Homo sapiens | - |
isoenzyme AC9 | - |
| Homo sapiens | O43306 | isoenzyme AC | - |
| Homo sapiens | O60266 | isoenzyme AC3 | - |
| Homo sapiens | O95622 | isoenzyme AC4 | - |
| Homo sapiens | P40145 | isoenzyme AC8 | - |
| Homo sapiens | P51828 | isoenzyme AC7 | - |
| Homo sapiens | Q08462 | isoenzyme AC2 | - |
| Homo sapiens | Q08828 | isoenzyme AC1 | - |
| Homo sapiens | Q96PN6 | isoenzyme AC | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | activation by protein kinase C phosphorylation | Homo sapiens |
| phosphoprotein | activytion by protein kinase C phosphorylation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | - |
Homo sapiens | 3',5'-cyclic AMP + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AC1 | - |
Homo sapiens |
| AC2 | - |
Homo sapiens |
| AC3 | - |
Homo sapiens |
| AC4 | - |
Homo sapiens |
| AC5 | - |
Homo sapiens |
| AC6 | - |
Homo sapiens |
| AC7 | - |
Homo sapiens |
| AC8 | - |
Homo sapiens |
| AC9 | - |
Homo sapiens |
| adenylyl cyclase | - |
Homo sapiens |
| soluble AC | - |
Homo sapiens |
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