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Literature summary for 4.5.1.3 extracted from

  • Blocki, F.A.; Logan, M.S.P.; Baoli, C.; Wackett, L.P.
    Reaction of rat liver glutathione S-trnasferase and bacterial dichloromethane dehalogenase with dihalomethanes (1994), J. Biol. Chem., 269, 8826-8830.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glutathione required Methylophilus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dichloromethane + H2O Methylophilus sp.
-
formaldehyde + Cl-
-
?
dichloromethane + H2O Methylophilus sp. DM11
-
formaldehyde + Cl-
-
?

Organism

Organism UniProt Comment Textmining
Methylophilus sp. P43387
-
-
Methylophilus sp. DM11 P43387
-
-

Purification (Commentary)

Purification (Comment) Organism
strain DM11 Methylophilus sp.

Reaction

Reaction Comment Organism Reaction ID
dichloromethane + H2O = formaldehyde + 2 chloride nucleophilic attack of glutathione on CH2Cl2 to produce a halomethylthioether intermediate Methylophilus sp.

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dichloromethane + H2O
-
Methylophilus sp. formaldehyde + Cl-
-
?
dichloromethane + H2O
-
Methylophilus sp. DM11 formaldehyde + Cl-
-
?