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Literature summary for 4.5.1.1 extracted from

  • Dinamarca, M.L.; Levenbook, L.; Valdes, E.
    DDT-dehydrochlorinase. II. Subunits, sulfhydryl groups, and chemical composition (1971), Arch. Biochem. Biophys., 147, 374-383.
    View publication on PubMed
Search for more literature for 4.5.1.1

Activating Compound

Activating Compound Comment Organism Structure
GSH required Musca domestica
GSH stabilizes tetrameric enzyme form Musca domestica

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoate i.e. PCMB. 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane completely protects the fully aggregated enzyme against PCMB inhibition Musca domestica

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 4 * 30000, disc electrophoresis Musca domestica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane Musca domestica
-
 ?
-
 ?
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane Musca domestica P2/sel
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Musca domestica
-
-
-
Musca domestica
-
 DDT-restistant housedly
-
Musca domestica P2/sel
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification phospholipoprotein Musca domestica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica P2/sel 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica ?
-
 ?
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica P2/sel ?
-
 ?

Subunits

Subunits Comment Organism
tetramer 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane induces aggregation of the enzyme into the active tetrameric form Musca domestica
tetramer 4 * 30000, disc electrophoresis Musca domestica
tetramer dissociation of the tetrameric enzyme by mercaptoethanol or dithiothreitol Musca domestica
trimer the trimeric enzyme is 10% as active as the tetrameric form Musca domestica