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Literature summary for 4.5.1.1 extracted from

  • Lipke, H.; Kearns, C.W.
    DDT dehydrochlorinase. II. Substrate and cofactor specificity (1959), J. Biol. Chem., 234, 2129-2132.
    View publication on PubMed
Search for more literature for 4.5.1.1

Activating Compound

Activating Compound Comment Organism Structure
cysteinylglycine activates Musca domestica

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate inhibition to a minor degree, completely reversible Musca domestica

Metals/Ions

Metals/Ions Comment Organism Structure
Al3+ stimulates at a concentration of 0.1 mM Musca domestica
Ca2+ stimulates at a concentration of 0.1 mM Musca domestica
Cu2+ stimulates at a concentration of 0.1 mM Musca domestica
Fe2+ stimulates at a concentration of 0.1 mM Musca domestica
Mg2+ stimulates at a concentration of 0.1 mM Musca domestica
Mn2+ stimulates at a concentration of 0.1 mM Musca domestica
Zn2+ stimulates at a concentration of 0.1 mM Musca domestica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane Musca domestica
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Musca domestica
-
 DDT-restistant housedly
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,1,1-trichloro-2,2-bis(4-bromophenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane
-
 Musca domestica ?
-
 ?
1,1,1-trichloro-2,2-bis(4-fluorophenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-iodophenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane
-
 Musca domestica ? + HCl
-
 ?
1,1,1-trichloro-2,2-bis(4-tolyl)ethane
-
 Musca domestica ? + HCl
-
 ?
1,1-dichloro-2,2-bis(4-chlorophenyl)ethane i.e. TDE, reaction velocity is 4 times the rate of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane, i.e. DDT Musca domestica 1-chloro-2,2-bis(4-chlorophenyl)ethylene + HCl
-
 ?