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Literature summary for 4.4.1.9 extracted from

  • Stauber, E.J.; Kuczka, P.; van Ohlen, M.; Vogt, B.; Janowitz, T.; Piotrowski, M.; Beuerle, T.; Wittstock, U.
    Turning the mustard oil bomb into a cyanide bomb: aromatic glucosinolate metabolism in a specialist insect herbivore (2012), PLoS ONE, 7, e35545.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.9

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + hydrogen cyanide Pieris rapae larvae incorporate cyanide into beta-cyanoalanine and thiocyanide hydrogen sulfide + L-3-cyanoalanine
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Organism

Organism UniProt Comment Textmining
Pieris rapae
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Source Tissue

Source Tissue Comment Organism Textmining
larva association of Pierid butterflies and plants of the Brassicales, Pierid rapae larvae develop on transgenic Arabidopsis plants with ectopic production of the cyanogenic glucoside dhurrin without ill effects. Larvae are fed on Arabidopsis thaliana Col-0 leaves to which either benzylglucosinolate or 2-phenylethylglucosinolate as exogenous glucosinolates are applied Pieris rapae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + hydrogen cyanide
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 Pieris rapae hydrogen sulfide + L-3-cyanoalanine
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 ?
L-cysteine + hydrogen cyanide larvae incorporate cyanide into beta-cyanoalanine and thiocyanide Pieris rapae hydrogen sulfide + L-3-cyanoalanine
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 ?

General Information

General Information Comment Organism
evolution the ability of Pierid species to safely handle cyanide contributed to the primary host shift from Fabales to Brassicales that occured about 75 million years ago and was followed by Pierid species diversification Pieris rapae
physiological function the enzyme detoxifies cyanide, larvae incorporate cyanide into beta-cyanoalanine and thiocyanide Pieris rapae