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Literature summary for 4.4.1.9 extracted from

  • Warrilow, A.G.S.; Hawkesford, M.J.
    Cysteine synthase (O-acetylserine (thiol) lyase) substrate specificities classify the mitochondrial isoform as a cyanoalanine synthase (2000), J. Exp. Bot., 51, 985-993.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-chloro-L-alanine substrate inhibition Spinacia oleracea
L-cysteine substrate inhibition Spinacia oleracea
O-acetyl-L-serine substrate inhibition Spinacia oleracea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.41
-
L-cysteine 26°C, pH 9.8 Spinacia oleracea
0.6
-
3-chloro-L-alanine 26°C, pH 9.8 Spinacia oleracea
9.73
-
O-acetyl-L-serine 26°C, pH 9.8 Spinacia oleracea

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33500
-
2 * 33500, SDS-PAGE Spinacia oleracea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + HCN Spinacia oleracea
-
sulfide + L-3-cyanoalanine
-
?
O-acetyl-L-serine + sulfide Spinacia oleracea
-
L-cysteine + acetate
-
?

Organism

Organism UniProt Comment Textmining
Spinacia oleracea
-
L. cv. Medina
-

Purification (Commentary)

Purification (Comment) Organism
-
Spinacia oleracea

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Spinacia oleracea
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chloroalanine + sulfide
-
Spinacia oleracea L-cysteine + Cl-
-
?
L-cysteine + HCN
-
Spinacia oleracea sulfide + L-3-cyanoalanine
-
?
L-cysteine + HCN 73% of activity with chloroanaline Spinacia oleracea sulfide + L-3-cyanoalanine
-
?
O-acetyl-L-serine + sulfide
-
Spinacia oleracea L-cysteine + acetate
-
?
O-acetyl-L-serine + sulfide 2.35% of activity with chloroanaline Spinacia oleracea L-cysteine + acetate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 33500, SDS-PAGE Spinacia oleracea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
-
Spinacia oleracea

pH Range

pH Minimum pH Maximum Comment Organism
10 11.5 sharp decrease in activity below pH 10.0, 15% of maximal activity at pH 11.5 Spinacia oleracea

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Spinacia oleracea

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.22
-
L-cysteine 26°C, pH 9.8 Spinacia oleracea
6.9
-
3-chloro-L-alanine 26°C, pH 9.8 Spinacia oleracea
38.1
-
O-acetyl-L-serine 26°C, pH 9.8 Spinacia oleracea