Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.3 extracted from

  • Wang, P.; Chen, X.L.; Li, C.Y.; Gao, X.; Zhu, D.Y.; Xie, B.B.; Qin, Q.L.; Zhang, X.Y.; Su, H.N.; Zhou, B.C.; Xun, L.Y.; Zhang, Y.Z.
    Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial dimethylsulfoniopropionate lyase a new enzyme from an old fold (2015), Mol. Microbiol., 98, 289-301 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Ruegeria lacuscaerulensis

Crystallization (Commentary)

Crystallization (Comment) Organism
wild-type in complex with inhibitor 2-(N-morpholino)ethanesulfonic acid or PO43-, to 2.1 A resolution, and mutants Y366A and D377N bound to acrylate Ruegeria lacuscaerulensis

Protein Variants

Protein Variants Comment Organism
D377A complete loss of activity Ruegeria lacuscaerulensis
D377N about 10% residual activity Ruegeria lacuscaerulensis
Y366A 20% residual activity Ruegeria lacuscaerulensis

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 10 mM, almost complete inhibition Ruegeria lacuscaerulensis
2-(N-morpholino)ethanesulfonic acid
-
Ruegeria lacuscaerulensis
bipyridyl 10 mM, 50% inhibition Ruegeria lacuscaerulensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
17.1
-
beta-dimethylsulfoniopropanoate pH 6.0, 60°C Ruegeria lacuscaerulensis

Organism

Organism UniProt Comment Textmining
Ruegeria lacuscaerulensis D0CY07
-
-
Ruegeria lacuscaerulensis DSM 11314 D0CY07
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-dimethylsulfoniopropanoate
-
Ruegeria lacuscaerulensis dimethylsulfide + acrylate
-
?
beta-dimethylsulfoniopropanoate
-
Ruegeria lacuscaerulensis DSM 11314 dimethylsulfide + acrylate
-
?
additional information enzyme shows no detectable activity toward the typical substrate (Val-Pro) of M24 peptidases Ruegeria lacuscaerulensis ?
-
?
additional information enzyme shows no detectable activity toward the typical substrate (Val-Pro) of M24 peptidases Ruegeria lacuscaerulensis DSM 11314 ?
-
?

Synonyms

Synonyms Comment Organism
dddP
-
Ruegeria lacuscaerulensis
SL1157_2466
-
Ruegeria lacuscaerulensis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
-
Ruegeria lacuscaerulensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Ruegeria lacuscaerulensis

Expression

Organism Comment Expression
Ruegeria lacuscaerulensis the expression of the dddP gene is significantly induced by DMSP but not by peptide Val-Pro or casein up