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Literature summary for 4.4.1.20 extracted from

  • Zhang, Z.; Lv, Z.; Wei, Z.; Li, C.; Shao, Y.; Zhang, W.; Zhao, X.; Xiong, J.
    Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus (2017), Mol. Immunol., 91, 114-122 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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Apostichopus japonicus 16020
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microsome
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Apostichopus japonicus
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Organism

Organism UniProt Comment Textmining
Apostichopus japonicus A0A219VGM9 bifunctional enzyme, acts as glutathione transferase and LTC4 synthase
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Source Tissue

Source Tissue Comment Organism Textmining
coelomocyte and muscle, lowest expression level Apostichopus japonicus
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intestine highest expression level Apostichopus japonicus
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additional information ubiquitously expressed in all examined tissues Apostichopus japonicus
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muscle and coelomocytes, lowest expression level Apostichopus japonicus
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respiratory system and tentacle, second highest expression level Apostichopus japonicus
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tentacle and respiratory tree, second highest expression level Apostichopus japonicus
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Subunits

Subunits Comment Organism
? x * 18810, calculated from sequence Apostichopus japonicus

pI Value

Organism Comment pI Value Maximum pI Value
Apostichopus japonicus calculated from sequence
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9.4

General Information

General Information Comment Organism
physiological function GST2 knock-down by specific siRNA significantly depresses LTC4 contents with 27.0 % decrease at 24 h. Reactive oxygen species levels are elevated by 40.1% in vitro. Increased expression of GST2 leads to 1.56fold increase in LTC4 synthase activity Apostichopus japonicus