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Literature summary for 4.4.1.20 extracted from

  • Liening, S.; Scriba, G.K.; Rummler, S.; Weinigel, C.; Kleinschmidt, T.K.; Haeggstroem, J.Z.; Werz, O.; Garscha, U.
    Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors (2016), Biochim. Biophys. Acta, 1861, 1605-1613 .
    View publication on PubMed
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Application

Application Comment Organism
analysis cell-free and cell-based assay systems based on in situ-generated LTA4 that allow studying LTC4S activity and investigating LTC4S inhibitors Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transfection of HEK 293 cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-[5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acid tandem benzophenone amino pyridine inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16873
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
LTC4 synthase
-
 Homo sapiens
LTC4S
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000017
-
 cell-free assay, the substrate LTA4 is produced in situ, 37°C, pH not specified in the publication Homo sapiens 5-[5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acid

General Information

General Information Comment Organism
physiological function transcellular LTC4 biosynthesis takes place between neutrophils or 5-lipoxygenase-expressing HEK293 cells that produce LTA4 from arachidonic acid and HEK293 cells expressing LTC4S that transform LTA4 to LTC4 Homo sapiens