Application | Comment | Organism |
---|---|---|
medicine | the C allele of the A-444C polymorphism is a risk factor for aspirin-induced urticaria in a Venezuelan population and may be a genetic marker for this phenotype. This single-nucleotide polymorphism is mainly associated with the cutaneous clinical pattern and with low skin response to histamine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
leukotriene C4 synthase | - |
Homo sapiens |
LTC4S | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | A-444C polymorphism on the LTC4S gene is associated with aspirin-induced urticaria. The C allele is more frequent in patients with the cutaneous pattern of aspirin-induced urticaria and in patients with low skin reactivity to histamine. There is no association between A-444C and asthma, atopy, or total IgE levels | Homo sapiens |