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Literature summary for 4.4.1.20 extracted from

  • Sanchez-Borges, M.; Acevedo, N.; Vergara, C.; Jimenez, S.; Zabner-Oziel, P.; Monzon, A.; Caraballo, L.
    The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria (2009), J. Investig. Allergol. Clin. Immunol., 19, 375-382.
    View publication on PubMed

Application

Application Comment Organism
medicine the C allele of the A-444C polymorphism is a risk factor for aspirin-induced urticaria in a Venezuelan population and may be a genetic marker for this phenotype. This single-nucleotide polymorphism is mainly associated with the cutaneous clinical pattern and with low skin response to histamine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
leukotriene C4 synthase
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Homo sapiens
LTC4S
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Homo sapiens

General Information

General Information Comment Organism
physiological function A-444C polymorphism on the LTC4S gene is associated with aspirin-induced urticaria. The C allele is more frequent in patients with the cutaneous pattern of aspirin-induced urticaria and in patients with low skin reactivity to histamine. There is no association between A-444C and asthma, atopy, or total IgE levels Homo sapiens