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Literature summary for 4.4.1.20 extracted from

  • Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.
    Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase (1998), Biochim. Biophys. Acta, 1391, 157-168.
    View publication on PubMed
Search for more literature for 4.4.1.20

Inhibitors

Inhibitors Comment Organism Structure
L-699,333 i.e. 2,[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-c,d]indol-2-yl]ethoxy]butanoic acid, reversible, competitive against glutathione and non-competitive against leukotriene A4 Homo sapiens
leukotriene A4 substrate inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 glutathione pH 7.4, 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound to Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
leukotriene C4 = leukotriene A4 + glutathione random rapid equilibrium mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0023
-
 leukotriene A4 pH 7.4, 25°C Homo sapiens