Any feedback?
Literature summary for 4.4.1.20 extracted from
- The biochemical, molecular, and genomic aspects of leukotriene C4 synthase (1999), Proc. Assoc. Am. Phys., 111, 537-546.
No PubMed abstract available
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A52S | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
| N55A | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
| R51H | fully active mutant enzyme | Homo sapiens |
| R51K | fully active mutant enzyme | Homo sapiens |
| V49F | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
| Y59F | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
| Y93F | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
| Y93F | activity of the mutant enzyme is less than 1% of the wild-type enzyme, shift in pH optimum of the residual activity to that of spontaneous conjugation | Homo sapiens |
| Y97F | mutation increases the Km-value for the recombinant enzyme for glutathione | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0099 | - |
leukotriene A4 | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Cavia porcellus | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| perinuclear space | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16567 | - |
x * 16567, calculation from nucleotide sequence | Homo sapiens |
| 18000 | - |
x * 18000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eosinophil | - |
Homo sapiens | - |
| KG-1 cell | - |
Homo sapiens | - |
| lung | - |
Cavia porcellus | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| mast cell | - |
Mus musculus | - |
| mast cell | - |
Homo sapiens | - |
| platelet | - |
Homo sapiens | - |
| THP-1 cell | monocytic leukemia cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Cavia porcellus | leukotriene C4 + H2O | - |
? | |
| leukotriene A4 + glutathione | - |
Mus musculus | leukotriene C4 + H2O | - |
? | |
| leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 18000, SDS-PAGE | Homo sapiens |
| ? | x * 16567, calculation from nucleotide sequence | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
