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Literature summary for 4.4.1.16 extracted from

  • Esaki, N.; Nakamura, T.; Tanaka, H.; Soda, K.
    Selenocysteine lyase, a novel enzyme that specifically acts on selenocysteine (1982), J. Biol. Chem., 257, 4386-4391.
    View publication on PubMed

General Stability

General Stability Organism
1% bovine serum albumin, 20% sucrose or 20% glycerol protects against inactivation, highly diluted samples sensitive to freezing Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine competitive Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.83
-
L-selenocysteine pH 8.5, 37°C Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
SDS-PAGE Sus scrofa
85000
-
sedimentation equilibrium centrifugation Sus scrofa
93000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-selenocysteine + reduced acceptor Cavia porcellus
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Mus musculus
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Rattus norvegicus
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Bos taurus
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Oryctolagus cuniculus
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Canis lupus familiaris
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Felis catus
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Platyrrhini
-
selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor Sus scrofa most likely metabolizes small amounts of selenocysteine in tissue selenide + L-alanine + acceptor
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Felis catus
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Platyrrhini
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
-
adrenal gland
-
Sus scrofa
-
brain low activity Rattus norvegicus
-
brain low activity Canis lupus familiaris
-
heart
-
Sus scrofa
-
heart low activity Rattus norvegicus
-
heart low activity Canis lupus familiaris
-
kidney highest activity Cavia porcellus
-
kidney highest activity Mus musculus
-
kidney highest activity Rattus norvegicus
-
kidney highest activity Sus scrofa
-
kidney highest activity Oryctolagus cuniculus
-
kidney highest activity Canis lupus familiaris
-
kidney highest activity Felis catus
-
liver highest activity Cavia porcellus
-
liver highest activity Mus musculus
-
liver highest activity Rattus norvegicus
-
liver highest activity Sus scrofa
-
liver highest activity Bos taurus
-
liver highest activity Oryctolagus cuniculus
-
liver highest activity Canis lupus familiaris
-
liver highest activity Felis catus
-
liver highest activity Platyrrhini
-
lung
-
Rattus norvegicus
-
lung
-
Canis lupus familiaris
-
additional information no activity in fat and blood Rattus norvegicus
-
muscle
-
Sus scrofa
-
muscle low activity Rattus norvegicus
-
pancreas low activity Mus musculus
-
pancreas low activity Oryctolagus cuniculus
-
pancreas high activity Rattus norvegicus
-
pancreas high activity Canis lupus familiaris
-
spleen
-
Rattus norvegicus
-
spleen
-
Canis lupus familiaris
-
testis low activity Rattus norvegicus
-
thymus
-
Rattus norvegicus
-
thymus
-
Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
37
-
purified enzyme, pH 8.5, 37°C Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, 20% sucrose, stable Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-selenocysteine + reduced acceptor
-
Cavia porcellus selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Mus musculus selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Rattus norvegicus selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Bos taurus selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Oryctolagus cuniculus selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Canis lupus familiaris selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Felis catus selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Platyrrhini selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor
-
Sus scrofa selenide + L-alanine + acceptor H2Se detected as product ?
L-selenocysteine + reduced acceptor most likely metabolizes small amounts of selenocysteine in tissue Sus scrofa selenide + L-alanine + acceptor
-
?

Subunits

Subunits Comment Organism
dimer 2 * 48000, SDS-PAGE Sus scrofa

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
50% of activity lost within 30 min Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required Cavia porcellus
pyridoxal 5'-phosphate required Mus musculus
pyridoxal 5'-phosphate required Rattus norvegicus
pyridoxal 5'-phosphate required Sus scrofa
pyridoxal 5'-phosphate required Bos taurus
pyridoxal 5'-phosphate required Oryctolagus cuniculus
pyridoxal 5'-phosphate required Canis lupus familiaris
pyridoxal 5'-phosphate required Felis catus
pyridoxal 5'-phosphate required Platyrrhini
pyridoxal 5'-phosphate completely inactive when cofactor is removed, can not be replaced by vitamin B6 derivatives Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1
-
L-cysteine pH 8.5, 37°C Sus scrofa