Literature summary for 4.4.1.13 extracted from

Katayama, R.; Nagata, S.; Iida, H.; Yamagishi, N.; Yamashita, T.; Furuhama, K.
Possible role of cysteine-S-conjugate beta-lyase in species differences in cisplatin nephrotoxicity (2011), Food Chem. Toxicol., 49, 2053-2059.

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Inhibitors

Inhibitors	Comment	Organism	Structure
aminooxyacetic acid hemihydrochloride	-	Canis lupus familiaris
aminooxyacetic acid hemihydrochloride	-	Felis sp.
aminooxyacetic acid hemihydrochloride	-	Mus musculus
aminooxyacetic acid hemihydrochloride	-	Oryctolagus cuniculus
aminooxyacetic acid hemihydrochloride	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-
mitochondrion	-	Rattus norvegicus	5739	-
mitochondrion	-	Oryctolagus cuniculus	5739	-
mitochondrion	-	Canis lupus familiaris	5739	-
mitochondrion	-	Felis sp.	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
37000	-	x * 37000, about, SDS-PAGE	Mus musculus
37000	-	x * 37000, about, SDS-PAGE	Rattus norvegicus
37000	-	x * 37000, about, SDS-PAGE	Oryctolagus cuniculus
37000	-	x * 37000, about, SDS-PAGE	Canis lupus familiaris
37000	-	x * 37000, about, SDS-PAGE	Felis sp.

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-
Canis lupus familiaris Madnine Darbine	-	-	-
Felis sp.	-	-	-
Mus musculus	-	-	-
Mus musculus BALB/cCrSlc	-	-	-
Oryctolagus cuniculus	-	-	-
Oryctolagus cuniculus New Zealand White	-	-	-
Rattus norvegicus	-	-	-
Rattus norvegicus Fischer 344	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	-	Mus musculus	-
cell culture	-	Rattus norvegicus	-
kidney	-	Mus musculus	-
kidney	-	Rattus norvegicus	-
kidney	-	Oryctolagus cuniculus	-
kidney	-	Canis lupus familiaris	-
kidney	-	Felis sp.	-
renal cortex	-	Mus musculus	-
renal cortex	-	Rattus norvegicus	-
renal cortex	-	Oryctolagus cuniculus	-
renal cortex	-	Canis lupus familiaris	-
renal cortex	-	Felis sp.	-

Subunits

Subunits	Comment	Organism
?	x * 37000, about, SDS-PAGE	Mus musculus
?	x * 37000, about, SDS-PAGE	Rattus norvegicus
?	x * 37000, about, SDS-PAGE	Oryctolagus cuniculus
?	x * 37000, about, SDS-PAGE	Canis lupus familiaris
?	x * 37000, about, SDS-PAGE	Felis sp.

Synonyms

Synonyms	Comment	Organism
C-S lyase	-	Mus musculus
C-S lyase	-	Rattus norvegicus
C-S lyase	-	Oryctolagus cuniculus
C-S lyase	-	Canis lupus familiaris
C-S lyase	-	Felis sp.

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition reduces renal injuries due to cisplatin in rats. The cytotoxicity of cisplatin is dependent on the expression level of enzyme mRNA in the respective renal cells	Rattus norvegicus
malfunction	the cytotoxicity of cisplatin is dependent on the expression level of enzyme mRNA in the respective renal cells	Mus musculus
malfunction	the cytotoxicity of cisplatin is dependent on the expression level of enzyme mRNA in the respective renal cells	Oryctolagus cuniculus
malfunction	the cytotoxicity of cisplatin is dependent on the expression level of enzyme mRNA in the respective renal cells	Canis lupus familiaris
malfunction	the cytotoxicity of cisplatin is dependent on the expression level of enzyme mRNA in the respective renal cells	Felis sp.
metabolism	the enzyme may play a crucial role in the metabolism of platinum-cysteine conjugates	Mus musculus
metabolism	the enzyme may play a crucial role in the metabolism of platinum-cysteine conjugates	Rattus norvegicus
metabolism	the enzyme may play a crucial role in the metabolism of platinum-cysteine conjugates	Oryctolagus cuniculus
metabolism	the enzyme may play a crucial role in the metabolism of platinum-cysteine conjugates	Canis lupus familiaris
metabolism	the enzyme may play a crucial role in the metabolism of platinum-cysteine conjugates	Felis sp.

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Release 2023.1 (January 2023)