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Literature summary for 4.4.1.13 extracted from

  • Cooper, A.J.; Krasnikov, B.F.; Niatsetskaya, Z.V.; Pinto, J.T.; Callery, P.S.; Villar, M.T.; Artigues, A.; Bruschi, S.A.
    Cysteine S-conjugate beta-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents (2011), Amino Acids, 41, 7-27.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
alpha-keto-gamma-methiolbutyrate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
93000
-
enzyme from rat kidney mitochondrion, most of the activity is present in the low-molecular weight fraction, gel filtration Rattus norvegicus
200000
-
enzyme from rat kidney mitochondrion, some activity is present in the high-molecular weight fraction, gel filtration Rattus norvegicus
330000
-
enzyme from rat kidney cytosol, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus cysteine S-conjugate beta-lyases catalyze beta-elimination reactions with cysteine S-conjugates that possess a good leaving group in the beta-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacrylate tautomerizes and hydrolyzes to pyruvate and ammonia. ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-1,1,2,2-tetrafluoroethyl-L-cysteine + H2O
-
Rattus norvegicus ? + NH3 + pyruvate
-
?
additional information cysteine S-conjugate beta-lyases catalyze beta-elimination reactions with cysteine S-conjugates that possess a good leaving group in the beta-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacrylate tautomerizes and hydrolyzes to pyruvate and ammonia. Rattus norvegicus ?
-
?
RS-CH2-CH(NH3+)COO- + H2O
-
Rattus norvegicus RSH + NH3 + pyruvate
-
?
S-1,2-dichlorovinyl-L-cysteine + H2O
-
Rattus norvegicus dichlorovinyl mercaptane + NH3 + pyruvate
-
?

Synonyms

Synonyms Comment Organism
cysteine S-conjugate beta-lyase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate pyridoxal 5'-phosphate-containing enzyme Rattus norvegicus