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Literature summary for 4.4.1.13 extracted from

  • Zhang, L.; Hanigan, M.H.
    Role of cysteine S-conjugate beta-lyase in the metabolism of cisplatin (2003), J. Pharmacol. Exp. Ther., 306, 988-994.
    View publication on PubMed

Application

Application Comment Organism
medicine renal toxicity of cisplatin is dependent on enzyme activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cisplatin is bioactivated by the enzyme, renal toxicity of cisplatin results from enzyme activity, in contrast, carboplatin is not bioactivated ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme expressed in LLC-PK1 cells
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cisplatin is bioactivated by the enzyme, renal toxicity of cisplatin results from enzyme activity, in contrast, carboplatin is not bioactivated Homo sapiens ?
-
?