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Literature summary for 4.4.1.13 extracted from

  • Cooper, A.J.; Bruschi, S.A.; Conway, M.; Hutson, S.M.
    Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation (2003), Biochem. Pharmacol., 65, 181-192.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
beta-chloro-L-alanine
-
Homo sapiens
8.4
-
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine 23°C, pH 7.4 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
enzymic activity of branched-chain aminotransferases
-

Reaction

Reaction Comment Organism Reaction ID
an L-cysteine-S-conjugate + H2O = a thiol + NH3 + pyruvate with an amino acid containing a good leaving group in the beta position, beta-elemination is greatly favoured over transamination Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-chloro-L-alanine
-
Homo sapiens ?
-
?
L-leucine + alpha-ketoglutarate
-
Homo sapiens ?
-
?
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
Homo sapiens ?
-
?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
Homo sapiens ?
-
?
S-(E-1,2-Dichlorovinyl)-L-cysteine
-
Homo sapiens ?
-
?