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Literature summary for 4.4.1.13 extracted from

  • Lash, L.H.; Elfarra, A.A.; Anders, M.W.
    Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane (1986), J. Biol. Chem., 261, 5930-5935.
    View publication on PubMed
Search for more literature for 4.4.1.13

Inhibitors

Inhibitors Comment Organism Structure
aminooxyacetic acid mitochondrial enzyme more sensitive than cytosolic Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.66
-
 S-(2-benzothiazolyl)-L-cysteine mitochondria Rattus norvegicus
1.02
-
 S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine mitochondria Rattus norvegicus
1.36
-
 S-(1,2-dichlorovinyl)-L-cysteine cytoplasm Rattus norvegicus
1.39
-
 S-(1,2-dichlorovinyl)-L-cysteine mitochondria Rattus norvegicus
1.66
-
 S-(2-benzothiazolyl)-L-cysteine cytoplasm Rattus norvegicus
1.78
-
 S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine cytoplasm Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion outer membrane Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 mitochondrial and cytosolic enzyme, distinct
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-benzothiazolyl-L-cysteine
-
 Rattus norvegicus pyruvate + NH3 + 2-mercaptobenzothiazole
-
 ?
benzothiazolyl-L-cysteine
-
 Rattus norvegicus ?
-
 ?
RSH-CH2-CH(NH3+)COO- R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene Rattus norvegicus RSH + NH3 + pyruvate
-
 ?
S-(1,2-dichloroethenyl)-L-cysteine + H2O
-
 Rattus norvegicus pyruvate + NH3 + dichlorovinyl mercaptane
-
 ?
S-(1,2-dichlorovinyl)-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + 1,2-dichloroethylenethiol
-
 ?
S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
 Rattus norvegicus ?
-
 ?