Activating Compound | Comment | Organism | Structure |
---|---|---|---|
PdxR | PdxR is a direct activator of the pdxST operon, has a regulatory function in de novo synthesis of pyridoxal 5'-phosphate, encoded by gene pdxR, PdxR is a member of the MocR/GabR subfamily with an N-terminal putative DNA-binding domain and a C-terminal aminotransferase-like domain. PdxR is also a negative autoregulator, and its ability to repress is increased by pyridoxal 5'-phosphate. PdxR-like proteins, for which PLP plays just a signalling role, form a separate functional group among the MocR/GabRtype proteins. Mutational analysis of the PdxR binding site, overview | Listeria monocytogenes |
Cloned (Comment) | Organism |
---|---|
gene lmo2101 or pdxS, encoding a subunit of pyridoxal 5'-phosphate synthase, quantitative PCR expression analysis, determination of transcription start points of genes pdxS and pdxR, overview | Listeria monocytogenes |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a deletion-insertion mutant replacing both the pdxS and pdxT genes with a spectinomycin-resistance cassette, introduction into the chromosome of Listeria monocytogenes strain EGD-e. Cell growth is fully restored by addition of pyridoxal or by complementation of the mutation | Listeria monocytogenes |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Listeria monocytogenes | Q8Y5G2 | gene lmo2101 or pdxS, encoding a subunit of pyridoxal 5'-phosphate synthase | - |