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Literature summary for 4.3.3.6 extracted from

  • Belitsky, B.R.
    Role of PdxR in the activation of vitamin B6 biosynthesis in Listeria monocytogenes (2014), Mol. Microbiol., 92, 1113-1128.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
PdxR PdxR is a direct activator of the pdxST operon, has a regulatory function in de novo synthesis of pyridoxal 5'-phosphate, encoded by gene pdxR, PdxR is a member of the MocR/GabR subfamily with an N-terminal putative DNA-binding domain and a C-terminal aminotransferase-like domain. PdxR is also a negative autoregulator, and its ability to repress is increased by pyridoxal 5'-phosphate. PdxR-like proteins, for which PLP plays just a signalling role, form a separate functional group among the MocR/GabRtype proteins. Mutational analysis of the PdxR binding site, overview Listeria monocytogenes

Cloned(Commentary)

Cloned (Comment) Organism
gene lmo2101 or pdxS, encoding a subunit of pyridoxal 5'-phosphate synthase, quantitative PCR expression analysis, determination of transcription start points of genes pdxS and pdxR, overview Listeria monocytogenes

Protein Variants

Protein Variants Comment Organism
additional information construction of a deletion-insertion mutant replacing both the pdxS and pdxT genes with a spectinomycin-resistance cassette, introduction into the chromosome of Listeria monocytogenes strain EGD-e. Cell growth is fully restored by addition of pyridoxal or by complementation of the mutation Listeria monocytogenes

Organism

Organism UniProt Comment Textmining
Listeria monocytogenes Q8Y5G2 gene lmo2101 or pdxS, encoding a subunit of pyridoxal 5'-phosphate synthase
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