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Literature summary for 4.3.3.2 extracted from

  • Vera-Reyes, I.; Huerta-Heredia, A.A.; Ponce-Noyola, T.; Flores-Sanchez, I.J.; Esparza-Garcia, F.; Cerda-Garcia-Rojas, C.M.; Trejo-Tapia, G.; Ramos-Valdivia, A.C.
    Strictosidine-related enzymes involved in the alkaloid biosynthesis of Uncaria tomentosa root cultures grown under oxidative stress (2013), Biotechnol. Prog., 29, 621-630.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene STR, semiquantitative RT-PCR expression analysis Uncaria tomentosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tryptamine + secologanin Uncaria tomentosa
-
 3-alpha(S)-strictosidine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Uncaria tomentosa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture line Utr-3a Uncaria tomentosa
-
root
-
 Uncaria tomentosa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-omega-methyltryptamine + secologanin
-
 Uncaria tomentosa dolichantoside + H2O
-
 ?
tryptamine + secologanin
-
 Uncaria tomentosa 3-alpha(S)-strictosidine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
str
-
 Uncaria tomentosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
 assay at Uncaria tomentosa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Uncaria tomentosa

Expression

Organism Comment Expression
Uncaria tomentosa enzyme expression is highly induced by oxidative stress, especially by buthionine sulfoximine-jasmonic acid, and also, to a lesser extent, by jasmonic acid and H2O2 up

General Information

General Information Comment Organism
metabolism the enzyme is involved in biosynthesis of 3-alpha(S)-strictosidine, a glycosylated indole alkaloid and central precursor of the entire monoterpenoid indole alkaloid biosynthesis, from tryptamine and secologanin and of dolichantoside from N-omega-methyltryptamine and secologanin Uncaria tomentosa
physiological function the enzyme is involved in biosynthesis of 3-alpha(S)-strictosidine, a glycosylated indole alkaloid and central precursor of the entire monoterpenoid indole alkaloid biosynthesis, from tryptamine and secologanin and of dolichantoside from N-omega-methyltryptamine and secologanin. Alkaloid production is associated to the antioxidant response induced under oxidative stress Uncaria tomentosa