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Literature summary for 4.3.3.2 extracted from

  • Stevens, L.H.; Giroud, C.; Pennings, E.J.M.; Verpoorte, R.
    Purification and characterization of strictosidine synthase from a suspension culture of Cinchona robusta (1993), Phytochemistry, 33, 99-106.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
3-alpha(S)-strictosidine
-
Cinchona robusta
chinconine
-
Cinchona robusta
cinchonidine
-
Cinchona robusta
corynantheal
-
Cinchona robusta
Cu2+
-
Cinchona robusta
Dihydroquinine
-
Cinchona robusta
additional information no substrate inhibition Catharanthus roseus
additional information no substrate inhibition Cinchona robusta
quinidine
-
Cinchona robusta
Quinine
-
Cinchona robusta
Tris
-
Cinchona robusta

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
tryptamine isoform I b Cinchona robusta
0.003
-
tryptamine isoform II b Cinchona robusta
0.008
-
tryptamine isoform I a Cinchona robusta
0.015
-
tryptamine isoform II a Cinchona robusta

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
SDS-PAGE, isoform I b and II b Cinchona robusta
35000
-
SDS-PAGE, isoforms I a and II a Cinchona robusta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tryptamine + secologanin Cinchona robusta involved in synthesis of monoterpenoid indole alkaloides 3-alpha(S)-strictosidine
-
?
tryptamine + secologanin Catharanthus roseus involved in synthesis of monoterpenoid indole alkaloides 3-alpha(S)-strictosidine
-
?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
-
-
-
Cinchona robusta
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Catharanthus roseus
glycoprotein all isoforms Cinchona robusta

Purification (Commentary)

Purification (Comment) Organism
hydrophobic interaction chromatography used for purification Cinchona robusta

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Cinchona robusta
-
cell culture
-
Catharanthus roseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-methoxytryptamine + secologanin 10% of activity Cinchona robusta 10-methoxystrictosidine
-
?
additional information 5-methoxytryptamine is not utilized Catharanthus roseus ?
-
?
tryptamine + secologanin
-
Cinchona robusta 3-alpha(S)-strictosidine
-
?
tryptamine + secologanin
-
Catharanthus roseus 3-alpha(S)-strictosidine
-
?
tryptamine + secologanin involved in synthesis of monoterpenoid indole alkaloides Cinchona robusta 3-alpha(S)-strictosidine
-
?
tryptamine + secologanin involved in synthesis of monoterpenoid indole alkaloides Catharanthus roseus 3-alpha(S)-strictosidine
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 8.5
-
Cinchona robusta

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9.5 50% activity Cinchona robusta

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.007
-
Quinine
-
Cinchona robusta