Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-alpha(S)-strictosidine | - |
Cinchona robusta | |
chinconine | - |
Cinchona robusta | |
cinchonidine | - |
Cinchona robusta | |
corynantheal | - |
Cinchona robusta | |
Cu2+ | - |
Cinchona robusta | |
Dihydroquinine | - |
Cinchona robusta | |
additional information | no substrate inhibition | Catharanthus roseus | |
additional information | no substrate inhibition | Cinchona robusta | |
quinidine | - |
Cinchona robusta | |
Quinine | - |
Cinchona robusta | |
Tris | - |
Cinchona robusta |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
tryptamine | isoform I b | Cinchona robusta | |
0.003 | - |
tryptamine | isoform II b | Cinchona robusta | |
0.008 | - |
tryptamine | isoform I a | Cinchona robusta | |
0.015 | - |
tryptamine | isoform II a | Cinchona robusta |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
SDS-PAGE, isoform I b and II b | Cinchona robusta |
35000 | - |
SDS-PAGE, isoforms I a and II a | Cinchona robusta |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
tryptamine + secologanin | Cinchona robusta | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
tryptamine + secologanin | Catharanthus roseus | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Catharanthus roseus | - |
- |
- |
Cinchona robusta | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Catharanthus roseus |
glycoprotein | all isoforms | Cinchona robusta |
Purification (Comment) | Organism |
---|---|
hydrophobic interaction chromatography used for purification | Cinchona robusta |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Cinchona robusta | - |
cell culture | - |
Catharanthus roseus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-methoxytryptamine + secologanin | 10% of activity | Cinchona robusta | 10-methoxystrictosidine | - |
? | |
additional information | 5-methoxytryptamine is not utilized | Catharanthus roseus | ? | - |
? | |
tryptamine + secologanin | - |
Cinchona robusta | 3-alpha(S)-strictosidine | - |
? | |
tryptamine + secologanin | - |
Catharanthus roseus | 3-alpha(S)-strictosidine | - |
? | |
tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Cinchona robusta | 3-alpha(S)-strictosidine | - |
? | |
tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Catharanthus roseus | 3-alpha(S)-strictosidine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 8.5 | - |
Cinchona robusta |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 9.5 | 50% activity | Cinchona robusta |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
Quinine | - |
Cinchona robusta |