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Literature summary for 4.3.3.2 extracted from
- Strictosidine synthase from cell cultrues of Apocynaceae plants (1979), FEBS Lett., 97, 159-162.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-chloromercuribenzoate | - |
Amsonia orientalis |  |
| p-chloromercuribenzoate | - |
Amsonia salicifolia | |
| p-chloromercuribenzoate | - |
Catharanthus roseus | |
| p-chloromercuribenzoate | - |
Ochrosia elliptica | |
| p-chloromercuribenzoate | - |
Rauvolfia vomitoria | |
| p-chloromercuribenzoate | - |
Stemmadenia tomentosa var. palmeri | |
| p-chloromercuribenzoate | - |
Vinca major | |
| p-chloromercuribenzoate | - |
Voacanga africana | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.6 | - |
secologanin | pH 7.0, 35°C | Rauvolfia vomitoria | |
| 5.8 | - |
tryptamine | pH 7.0, 35°C | Rauvolfia vomitoria | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tryptamine + secologanin | Catharanthus roseus | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Amsonia salicifolia | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Rauvolfia vomitoria | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Amsonia orientalis | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Vinca major | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Vinca minor | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Ochrosia elliptica | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Stemmadenia tomentosa var. palmeri | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | Voacanga africana | involved in synthesis of monoterpenoid indole alkaloides | 3-alpha(S)-strictosidine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Amsonia orientalis | - |
- |
- |
| Amsonia salicifolia | - |
- |
- |
| Catharanthus roseus | - |
- |
- |
| Ochrosia elliptica | - |
- |
- |
| Rauvolfia vomitoria | - |
- |
- |
| Stemmadenia tomentosa var. palmeri | - |
- |
- |
| Vinca major | - |
- |
- |
| Vinca minor | - |
- |
- |
| Voacanga africana | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Catharanthus roseus | - |
| cell culture | - |
Amsonia salicifolia | - |
| cell culture | - |
Rauvolfia vomitoria | - |
| cell culture | - |
Amsonia orientalis | - |
| cell culture | - |
Vinca major | - |
| cell culture | - |
Ochrosia elliptica | - |
| cell culture | - |
Stemmadenia tomentosa var. palmeri | - |
| cell culture | - |
Voacanga africana | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°, several months, no loss of activity | Catharanthus roseus |
| -20°, several months, no loss of activity | Amsonia salicifolia |
| -20°, several months, no loss of activity | Rauvolfia vomitoria |
| -20°, several months, no loss of activity | Amsonia orientalis |
| -20°, several months, no loss of activity | Vinca major |
| -20°, several months, no loss of activity | Ochrosia elliptica |
| -20°, several months, no loss of activity | Stemmadenia tomentosa var. palmeri |
| -20°, several months, no loss of activity | Voacanga africana |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tryptamine + secologanin | - |
Catharanthus roseus | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Amsonia salicifolia | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Rauvolfia vomitoria | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Amsonia orientalis | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Vinca major | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Vinca minor | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Ochrosia elliptica | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Stemmadenia tomentosa var. palmeri | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | - |
Voacanga africana | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Catharanthus roseus | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Amsonia salicifolia | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Rauvolfia vomitoria | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Amsonia orientalis | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Vinca major | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Vinca minor | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Ochrosia elliptica | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Stemmadenia tomentosa var. palmeri | 3-alpha(S)-strictosidine | - |
? | |
| tryptamine + secologanin | involved in synthesis of monoterpenoid indole alkaloides | Voacanga africana | 3-alpha(S)-strictosidine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Catharanthus roseus |
| monomer | - |
Amsonia salicifolia |
| monomer | - |
Rauvolfia vomitoria |
| monomer | - |
Amsonia orientalis |
| monomer | - |
Vinca major |
| monomer | - |
Ochrosia elliptica |
| monomer | - |
Stemmadenia tomentosa var. palmeri |
| monomer | - |
Voacanga africana |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | 50 | - |
Amsonia salicifolia |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7 | slightly higher activity in phosphate than in Tris/HCl buffer | Amsonia salicifolia |
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