Application | Comment | Organism |
---|---|---|
medicine | GGCT silencing significantly suppresses proliferation of colorectal cancer cells and arrests cell cycle at the G0/G1 phase by regulating the expression of p21, p27, and cyclin E. GGCT silencing triggers the apoptosis of colorectal cancer cells by activating caspase-3 and cleaved poly-ADPribose polymerase pathways and downregulating the phosphorylation proline-rich Akt substrate of 40 kDa (PRAS40) expression levels. GGCT silencing combined with 5-fluorouracil treatment further induces the apoptotic rate of colorectal cancer cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75223 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GGCT | - |
Homo sapiens |