Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.3.2.9 extracted from

  • Orlowski, M.; Meister, A.
    gamma-Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity (1973), J. Biol. Chem., 248, 2836-2844.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.6
-
5-L-glutamyl-5-L-glutamyl-p-nitroanilide
-
Rattus norvegicus
8
-
5-L-Glutamyl-L-alpha-aminobutyrate isoenzyme B Rattus norvegicus
10
-
5-L-Glutamyl-L-glutamine isoenzyme B Rattus norvegicus
12
-
5-L-Glutamyl-L-alpha-aminobutyrate isoenzyme A Rattus norvegicus
18
-
5-L-Glutamyl-L-glutamine isoenzyme A Rattus norvegicus
100
-
alpha-N-(gamma-L-glutamyl)-L-lysine isoenzyme A Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27500
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
immunologically identical isoenzymes A and B, ammonium sulfate, gel filtration, carboxymethylcellulose, DEAE-cellulose Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
additional information
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
8.9
-
isoenzyme B, substrate 5-L-glutamyl-5-L-glutamyl-p-nitroanilide Rattus norvegicus
9.7
-
isoenzyme B, substrate 5-L-glutamyl-L-alpha-aminobutyrate Rattus norvegicus
38
-
isoenzyme A, substrate 5-L-glutamyl-L-alpha-aminobutyrate Rattus norvegicus
40
-
isoenzyme A, substrate 5-L-glutamyl-5-L-glutamyl-p-nitroanilide Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-N-(5-L-glutamyl)L-lysine
-
Rattus norvegicus 5-oxoproline + L-lysine
-
?
5-L-glutamyl-5-L-glutamyl-4-nitroanilide
-
Rattus norvegicus 5-oxoproline + 5-L-glutamyl-4-nitroanilide
-
?
5-L-glutamyl-glycine poor substrate Rattus norvegicus 5-oxoproline + glycine
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
-
Rattus norvegicus 5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
?
5-L-glutamyl-L-5-L-glutamyl-L-4-nitroanilide
-
Rattus norvegicus Sprague-Dawley 5-L-oxoproline + 5-L-glutamyl-L-p-nitroanilide
-
?
5-L-glutamyl-L-6-N-benzyloxycarbonyl-L-lysine
-
Rattus norvegicus 5-oxoproline + L-6-N-benzyloxycarbonyl-L-lysine
-
?
5-L-glutamyl-L-alpha-aminobutyrate
-
Rattus norvegicus 5-L-oxoproline + L-alpha-aminobutyrate
-
?
5-L-glutamyl-L-alpha-aminobutyrate
-
Rattus norvegicus Sprague-Dawley 5-L-oxoproline + L-alpha-aminobutyrate
-
?
5-L-glutamyl-L-amino acid
-
Rattus norvegicus 5-oxoproline + L-amino acid i.e. 2-pyrrolidone-5-carboxylic acid ?
5-L-glutamyl-L-amino acid
-
Rattus norvegicus Sprague-Dawley 5-oxoproline + L-amino acid i.e. 2-pyrrolidone-5-carboxylic acid ?
5-L-glutamyl-L-glutamate poor substrate Rattus norvegicus 5-oxoproline + L-glutamate
-
?
5-L-glutamyl-L-glutamine best substrate Rattus norvegicus 5-oxoproline + L-glutamine
-
?
5-L-glutamyl-L-glutamine best substrate Rattus norvegicus Sprague-Dawley 5-oxoproline + L-glutamine
-
?
5-L-glutamyl-L-leucine poor substrate Rattus norvegicus 5-oxoproline + L-leucine
-
?
5-L-glutamyl-L-methionine best substrate Rattus norvegicus 5-oxoproline + L-methionine
-
?
5-L-glutamyl-L-methionine best substrate Rattus norvegicus Sprague-Dawley 5-oxoproline + L-methionine
-
?
alpha-N-(gamma-L-glutamyl)-L-lysine
-
Rattus norvegicus L-lysine + 5-oxo-L-proline
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Rattus norvegicus