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Literature summary for 4.3.2.2 extracted from
- Inhibition of defective adenylosuccinate lyase by HNE: a neurological disease that may be affected by oxidative stress (2005), Biofactors, 24, 131-136.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Bacillus subtilis |
| additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Homo sapiens |
| additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Thermotoga maritima |
| additional information | participates in the purine biosynthetic pathway, enzyme defects result in psychomotor retardation, epilepsy, muscle wasting and autistic features | Pyrobaculum aerophilum |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Bacillus subtilis |
- |
Thermotoga maritima |
- |
Pyrobaculum aerophilum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D422Y | mutant without enzyme activity | Homo sapiens |
| D430N | mutant without enzyme activity | Homo sapiens |
| L423V | mutant without enzyme activity | Homo sapiens |
| P110A/D422Y | heat sensitive mutant | Homo sapiens |
| R141W | thermostable mutant with decreased activity | Homo sapiens |
| R303C | thermostable mutant with decreased activity | Homo sapiens |
| R426H | mutant without enzyme activity | Homo sapiens |
| S395R | thermostable mutant with decreased activity | Homo sapiens |
| S438P | heat sensitive mutant without enzyme activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Bacillus subtilis | |
| additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Homo sapiens | |
| additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Pyrobaculum aerophilum | |
| additional information | dithiothreitol increases inhibition of trans-4-hydroxy-2-nonenal; hydroxylamine reverses inhibition of trans-4-hydroxy-2-nonenal | Thermotoga maritima | |
| nonenal | - |
Bacillus subtilis |  |
| nonenal | - |
Homo sapiens | |
| nonenal | - |
Pyrobaculum aerophilum | |
| nonenal | - |
Thermotoga maritima | |
| trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Bacillus subtilis | |
| trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Homo sapiens | |
| trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Pyrobaculum aerophilum | |
| trans-4-hydroxy-2-nonenal | 10-15 µM, inhibitor reacts both with the free enzyme and the enzyme substrate complex | Thermotoga maritima | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Bacillus subtilis | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Homo sapiens | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Thermotoga maritima | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | Pyrobaculum aerophilum | - |
5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| adenylosuccinate | Bacillus subtilis | - |
AMP + fumarate | - |
? | |
| adenylosuccinate | Homo sapiens | - |
AMP + fumarate | - |
? | |
| adenylosuccinate | Thermotoga maritima | - |
AMP + fumarate | - |
? | |
| adenylosuccinate | Pyrobaculum aerophilum | - |
AMP + fumarate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Pyrobaculum aerophilum | - |
- |
- |
| Thermotoga maritima | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Bacillus subtilis | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Homo sapiens | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Thermotoga maritima | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide | - |
Pyrobaculum aerophilum | 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate | - |
? | |
| adenylosuccinate | - |
Bacillus subtilis | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Homo sapiens | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Thermotoga maritima | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Pyrobaculum aerophilum | AMP + fumarate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Bacillus subtilis |
| homotetramer | - |
Homo sapiens |
| homotetramer | - |
Thermotoga maritima |
| homotetramer | - |
Pyrobaculum aerophilum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADSL | - |
Bacillus subtilis |
| ADSL | - |
Thermotoga maritima |
| ADSL | - |
Pyrobaculum aerophilum |
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Release 2023.1 (January 2023)
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