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Literature summary for 4.3.2.10 extracted from

  • Lipchock, J.; Loria, J.P.
    Millisecond dynamics in the allosteric enzyme imidazole glycerol phosphate synthase (IGPS) from Thermotoga maritima (2009), J. Biomol. NMR, 45, 73-84 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.3.2.10

Cloned(Commentary)

Cloned (Comment) Organism
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 Thermotoga maritima

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9X0C6 AND Q9X0C8 Q9X0C6: subunit HisF, Q9X0C8: subunit HisH
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Thermotoga maritima ATCC 43589 Q9X0C6 AND Q9X0C8 Q9X0C6: subunit HisF, Q9X0C8: subunit HisH
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Purification (Commentary)

Purification (Comment) Organism
-
 Thermotoga maritima

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine IGPS heterodimeric enzyme comprised of two proteins, HisH and HisF, that catalyze the hydrolysis of glutamine to produce NH3 in the HisH active site and the cyclization of ammonia with 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide in HisF to produce 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate. Binding of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate stimulates glutaminase activity in the HisH enzyme over 5000 and 100fold, respectively, despite the active sites being more than 25 A apart Thermotoga maritima 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate
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 ?
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine IGPS heterodimeric enzyme comprised of two proteins, HisH and HisF, that catalyze the hydrolysis of glutamine to produce NH3 in the HisH active site and the cyclization of ammonia with 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide in HisF to produce 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate. Binding of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate stimulates glutaminase activity in the HisH enzyme over 5000 and 100fold, respectively, despite the active sites being more than 25 A apart Thermotoga maritima ATCC 43589 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate
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 ?
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-ß-D-ribosyl)imidazole-4-carboxamide + NH3 IGPS heterodimeric enzyme comprised of two proteins, HisH and HisF, that catalyze the hydrolysis of glutamine to produce NH3 in the HisH active site and the cyclization of ammonia with 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide in HisF to produce 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate. Binding of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate stimulates glutaminase activity in the HisH enzyme over 5000 and 100-fold, respectively, despite the active sites being more than 25 A apart Thermotoga maritima 5-amino-1-(5-phospho-ß-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H2O
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 ?
5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-ß-D-ribosyl)imidazole-4-carboxamide + NH3 IGPS heterodimeric enzyme comprised of two proteins, HisH and HisF, that catalyze the hydrolysis of glutamine to produce NH3 in the HisH active site and the cyclization of ammonia with 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide in HisF to produce 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate. Binding of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate stimulates glutaminase activity in the HisH enzyme over 5000 and 100-fold, respectively, despite the active sites being more than 25 A apart Thermotoga maritima ATCC 43589 5-amino-1-(5-phospho-ß-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H2O
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 ?
L-glutamine + H2O IGPS heterodimeric enzyme comprised of two proteins, HisH and HisF, that catalyze the hydrolysis of glutamine to produce NH3 in the HisH active site and the cyclization of ammonia with 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide in HisF to produce 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate. Binding of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate stimulates glutaminase activity in the HisH enzyme over 5000- and 100fold, respectively, despite the active sites being more than 25 A apart Thermotoga maritima L-glutamate + NH3
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 ?
L-glutamine + H2O IGPS heterodimeric enzyme comprised of two proteins, HisH and HisF, that catalyze the hydrolysis of glutamine to produce NH3 in the HisH active site and the cyclization of ammonia with 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide in HisF to produce 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate. Binding of 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide and D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate stimulates glutaminase activity in the HisH enzyme over 5000- and 100fold, respectively, despite the active sites being more than 25 A apart Thermotoga maritima ATCC 43589 L-glutamate + NH3
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 ?

Synonyms

Synonyms Comment Organism
IGPS
-
 Thermotoga maritima