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Literature summary for 4.3.2.1 extracted from

  • Hung, Y.H.; Huang, H.L.; Chen, W.C.; Yen, M.C.; Cho, C.Y.; Weng, T.Y.; Wang, C.Y.; Chen, Y.L.; Chen, L.T.; Lai, M.D.
    Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells (2017), Oncol. Rep., 37, 969-978 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P04424
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-

Synonyms

Synonyms Comment Organism
ASL
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the arginine metabolic enzyme argininosuccinate lyase (ASL) promotes hepatocellular carcinoma formation in part via maintenance of cyclin A2 protein expression. Argininosuccinate lyase interacts with cyclin A2 in the cytoplasm and may promote phepatocellular carcinoma formation through this non-enzymatic function. Overexpression of ASL may be a contributing factor in drug resistance for arginine deprivation therapy Homo sapiens