Literature summary for 4.3.2.1 extracted from

Zhao, S.; Xu, W.; Jiang, W.; Yu, W.; Lin, Y.; Zhang, T.; Yao, J.; Zhou, L.; Zeng, Y.; Li, H.; Li, Y.; Shi, J.; An, W.; Hancock, S.; He, F.; Qin, L.; Chin, J.; Yang, P.; Chen, X.; Lei, Q.; Xiong, Y.; Guan, K.
Regulation of cellular metabolism by protein lysine acetylation (2010), Science, 327, 1000-1004.

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Activating Compound

Activating Compound	Comment	Organism	Structure
amino acids	extra amino acids in culture media increases activity of ASL by decreasing inhibitory acetylation rate	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
overexpressed in HEK293T cells or in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K288R	132% of wild-type activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
D-glucose	12.5 mM glucose decreases activity of ASL by 20%, 25 mM glucose by 50%	Homo sapiens
additional information	acetylation at Lys288 or Lys69 decreases activity of ASL	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
argininosuccinate	Homo sapiens	-	fumarate + L-Arg	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
side-chain modification	acetylation at Lys288 or Lys69 in liver decreases activity of ASL	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
argininosuccinate	-	Homo sapiens	fumarate + L-Arg	-	?
fumarate + arginine	-	Homo sapiens	argininosuccinate	-	r

Synonyms

Synonyms	Comment	Organism
Argininosuccinate lyase	-	Homo sapiens
ASL	-	Homo sapiens

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Release 2023.1 (January 2023)