Protein Variants | Comment | Organism |
---|---|---|
E296Q | retains only 0.001% residual activity | Anas platyrhynchos |
N116L | no activity | Anas platyrhynchos |
R115N | no activity | Anas platyrhynchos |
S283A | no activity | Anas platyrhynchos |
S384A | catalytic efficiency is decreased by an order of magnitude in comparison to wild-type delta II crystallin | Anas platyrhynchos |
T161V | no activity | Anas platyrhynchos |
Y323F | catalytic efficiency is decreased by an order of magnitude in comparison to wild-type delta II crystallin | Anas platyrhynchos |
Y323I | no activity | Anas platyrhynchos |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
argininosuccinate | mutant enzyme S284A | Anas platyrhynchos | |
0.03 | - |
argininosuccinate | mutant enzyme R113N | Anas platyrhynchos | |
0.07 | - |
argininosuccinate | wild-type enzyme | Anas platyrhynchos | |
0.09 | - |
argininosuccinate | mutant enzyme S114A | Anas platyrhynchos | |
0.4 | - |
argininosuccinate | - |
Anas platyrhynchos | |
1.7 | - |
argininosuccinate | mutant enzyme Y323F | Anas platyrhynchos |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Anas platyrhynchos | - |
wild type and mutant enzymes: S114A, R113N, S284A, Y323F, E296Q, r115N, N116L, T161V, S283A, and Y323I | - |
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2-(Nomega-L-arginino)succinate = fumarate + L-arginine | 5 residues are essential for catalytic activity: R115, N116, T161, S283, and E296 | Anas platyrhynchos |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Anas platyrhynchos | - |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.12 | - |
argininosuccinate | mutant enzyme S284A | Anas platyrhynchos | |
0.43 | - |
argininosuccinate | mutant enzyme Y323F | Anas platyrhynchos | |
0.62 | - |
argininosuccinate | mutant enzyme R113N | Anas platyrhynchos | |
2.42 | - |
argininosuccinate | mutant enzyme S114A | Anas platyrhynchos | |
3.28 | - |
argininosuccinate | - |
Homo sapiens | |
4.9 | - |
argininosuccinate | wild-type enzyme | Anas platyrhynchos |