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Literature summary for 4.3.1.7 extracted from
- Ethanolamine deaminase (Clostridium sp.) (1971), Methods Enzymol., 17B, 818-824.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-amino-2-propanol | - |
Clostridium sp. |  |
| 2-(dimethylamino)ethanol | - |
Clostridium sp. | |
| 2-(methylamino)ethanol | - |
Clostridium sp. | |
| 2-amino-1-butanol | - |
Clostridium sp. | |
| 3-aminopropanol | - |
Clostridium sp. | |
| cyanocobalamin | irreversible | Clostridium sp. | |
| DL-2-amino-1-propanol | - |
Clostridium sp. | |
| hydroxycobalamin | irreversible | Clostridium sp. | |
| L-2-Aminopropan-1-ol | - |
Clostridium sp. | |
| methylcobalamin | irreversible | Clostridium sp. | |
| Na+ | - |
Clostridium sp. | |
| p-chloromercuriphenylsulfonate | - |
Clostridium sp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.022 | - |
ethanolamine | - |
Clostridium sp. | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | required | Clostridium sp. | |
| K+ | Km: 0.47 mM | Clostridium sp. | |
| Rb+ | can replace K+ | Clostridium sp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
8-10 * 57000, equilibrium sedimentation after treatment with guanidinium hydrochloride | Clostridium sp. |
| 520000 | - |
equilibrium sedimentation | Clostridium sp. |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Clostridium sp. |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 14.1 | - |
- |
Clostridium sp. |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, enzyme concentration 4 mg/ml, 10% loss of activity after 8 days, considerably less stable at concentrations below 0.1 mg/ml | Clostridium sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethanolamine | - |
Clostridium sp. | acetaldehyde + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| oligomer | 8-10 * 57000, equilibrium sedimentation after treatment with guanidinium hydrochloride | Clostridium sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 8.2 | - |
Clostridium sp. |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cobamide | dependent on | Clostridium sp. | |
| cobamide | Km-values of cobamide coenzymes | Clostridium sp. | |
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Release 2023.1 (January 2023)
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