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Literature summary for 4.3.1.30 extracted from

  • Ruszczycky, M.W.; Choi, S.H.; Mansoorabadi, S.O.; Liu, H.W.
    Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose (2011), J. Am. Chem. Soc., 133, 7292-7295.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine Streptomyces venezuelae the enzyme is involved in biosynthesis of TDP-D-desosamine dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine
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Organism

Organism UniProt Comment Textmining
Streptomyces venezuelae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine
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 Streptomyces venezuelae dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine
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 ?
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine the enzyme is involved in biosynthesis of TDP-D-desosamine Streptomyces venezuelae dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine
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 ?
additional information when the enzyme is incubated with TDP-D-quinovose instead of the natural substrate dTDP-4-amino-4,6-dideoxy-D-glucopyranose, analogous elimination of the C4 hydroxyl is not observed - rather, the C3 hydroxyl is oxidized to the corresponding ketone. EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-Quinovose Streptomyces venezuelae ?
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 ?

Synonyms

Synonyms Comment Organism
DesII
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 Streptomyces venezuelae

Cofactor

Cofactor Comment Organism Structure
4Fe-4S-center a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity Streptomyces venezuelae
S-adenosyl-L-methionine a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity Streptomyces venezuelae