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Literature summary for 4.3.1.30 extracted from

  • Ruszczycky, M.W.; Choi, S.H.; Liu, H.W.
    Stoichiometry of the redox neutral deamination and oxidative dehydrogenation reactions catalyzed by the radical SAM enzyme DesII (2010), J. Am. Chem. Soc., 132, 2359-2369.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine Streptomyces venezuelae the enzyme is involved in biosynthesis of TDP-D-desosamine dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine
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 ?

Organism

Organism UniProt Comment Textmining
Streptomyces venezuelae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine the enzyme is involved in biosynthesis of TDP-D-desosamine Streptomyces venezuelae dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine
-
 ?
dTDP-4-amino-4,6-dideoxy-D-glucopyranose + S-adenosyl-L-methionine
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 Streptomyces venezuelae dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine
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 ?

Synonyms

Synonyms Comment Organism
DesII
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 Streptomyces venezuelae

Cofactor

Cofactor Comment Organism Structure
4Fe-4S-center [4Fe-4S]1+ is the catalytically active form of all radical S-adenosyl-L-methionine-dependent enzymes. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity Streptomyces venezuelae
S-adenosyl-L-methionine a radical S-adenosyl-L-methionine-dependent enzyme. Dependence on a [4Fe-4S] cluster and S-adenosyl-L-methionine for DesII activity. Radical S-adenosyl-L-methionine enzymes are an important class of biological catalysts involved in radical mediated transformations in both primary and secondary metabolic pathways. All of these enzymes contain a [4Fe-4S] cluster in the active-site and are S-adenosyl-L-methionine dependent. The reactions are initiated by a single electron transfer from the reduced [4Fe-4S]1+ cluster to SAM to induce the homolytic cleavage of the C5'-S bond in -adenosyl-L-methionine, which yields a reactive 5'-deoxyadenosyl radical along with L-methionine. The 5'-deoxyadenosyl radical is used to generate a substrate radical intermediate that is subsequently converted to product Streptomyces venezuelae