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Literature summary for 4.3.1.3 extracted from

  • Mehler, A.H.; Tabor, H.
    Deamination of histidine to form urocanic acid in liver (1953), J. Biol. Chem., 201, 775-784.
    View publication on PubMed
Search for more literature for 4.3.1.3

Inhibitors

Inhibitors Comment Organism Structure
CN- 0.01 M, 40% inhibition Cavia porcellus
EDTA 0.001 mM: 50% inhibition, 0.01 mM, complete inhibition Cavia porcellus
glycine 0.02 M glycine buffer, 40% inhibition. Inhibition can be overcome by addition of cations, including Mn2+, Ca2+, and Mg2+ Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cavia porcellus pathway of histidine metabolism, enzymatical synthesis of urocanic acid ?
-
 ?
additional information Pseudomonas fluorescens pathway of histidine metabolism, enzymatical synthesis of urocanic acid ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Pseudomonas fluorescens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Cavia porcellus
additional information
-
-
 Pseudomonas fluorescens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine natural substrate Cavia porcellus urocanate + NH3
-
 ?
L-histidine natural substrate Pseudomonas fluorescens urocanate + NH3
-
 ?
additional information pathway of histidine metabolism, enzymatical synthesis of urocanic acid Cavia porcellus ?
-
 ?
additional information pathway of histidine metabolism, enzymatical synthesis of urocanic acid Pseudomonas fluorescens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 EDTA
-
 Cavia porcellus