Application | Comment | Organism |
---|---|---|
medicine | enzyme substitution therapy for the treatment of phenylketonuria | Rhodotorula toruloides |
pharmacology | enzyme substitution therapy for the treatment of phenylketonuria | Rhodotorula toruloides |
synthesis | reconstructed phenylpropanoid pathway in engineered Escherichia coli or Saccharomyces cerevisiae leads to the biosynthesis of a wide range of phenylpropanoid-derived compounds, including pinocembrin, naringenin, styrene, 2',4',6'-trihydroxydihydrochalcone, trans-resveratrol, trans-cinnamic acid, p-coumarate, p-hydroxystyrene | Rhodotorula toruloides |
Protein Variants | Comment | Organism |
---|---|---|
R123A | modest improvements in resistance against protease inactivation | Rhodotorula toruloides |
R123H | modest improvements in resistance against protease inactivation | Rhodotorula toruloides |
R123Q | modest improvements in resistance against protease inactivation | Rhodotorula toruloides |
Y110A | modest improvements in resistance against protease inactivation | Rhodotorula toruloides |
Y110H | modest improvements in resistance against protease inactivation | Rhodotorula toruloides |
Y110L | modest improvements in resistance against protease inactivation | Rhodotorula toruloides |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine | Rhodotorula toruloides | key gateway enzyme linking the phenylpropanoid secondary pathway to primary metabolism | trans-cinnamate + NH3 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhodotorula toruloides | P11544 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine | - |
Rhodotorula toruloides | trans-cinnamate + NH3 | - |
r | |
L-phenylalanine | key gateway enzyme linking the phenylpropanoid secondary pathway to primary metabolism | Rhodotorula toruloides | trans-cinnamate + NH3 | - |
r | |
trans-cinnamate + NH3 | - |
Rhodotorula toruloides | L-phenylalanine | - |
r |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Rhodotorula toruloides |
Synonyms | Comment | Organism |
---|---|---|
PAL | - |
Rhodotorula toruloides |
General Information | Comment | Organism |
---|---|---|
metabolism | key gateway enzyme linking the phenylpropanoid secondary pathway to primary metabolism | Rhodotorula toruloides |