Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.3.1.25 extracted from

  • Kong, J.
    Phenylalanine ammonia-lyase, a key component used for phenylpropanoids production by metabolic engineering (2015), RSC Adv., 5, 62587-62603 .
No PubMed abstract available

Application

Application Comment Organism
medicine enzyme substitution therapy for the treatment of phenylketonuria Rhodotorula toruloides
pharmacology enzyme substitution therapy for the treatment of phenylketonuria Rhodotorula toruloides
synthesis reconstructed phenylpropanoid pathway in engineered Escherichia coli or Saccharomyces cerevisiae leads to the biosynthesis of a wide range of phenylpropanoid-derived compounds, including pinocembrin, naringenin, styrene, 2',4',6'-trihydroxydihydrochalcone, trans-resveratrol, trans-cinnamic acid, p-coumarate, p-hydroxystyrene Rhodotorula toruloides

Protein Variants

Protein Variants Comment Organism
R123A modest improvements in resistance against protease inactivation Rhodotorula toruloides
R123H modest improvements in resistance against protease inactivation Rhodotorula toruloides
R123Q modest improvements in resistance against protease inactivation Rhodotorula toruloides
Y110A modest improvements in resistance against protease inactivation Rhodotorula toruloides
Y110H modest improvements in resistance against protease inactivation Rhodotorula toruloides
Y110L modest improvements in resistance against protease inactivation Rhodotorula toruloides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine Rhodotorula toruloides key gateway enzyme linking the phenylpropanoid secondary pathway to primary metabolism trans-cinnamate + NH3
-
r

Organism

Organism UniProt Comment Textmining
Rhodotorula toruloides P11544
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine
-
Rhodotorula toruloides trans-cinnamate + NH3
-
r
L-phenylalanine key gateway enzyme linking the phenylpropanoid secondary pathway to primary metabolism Rhodotorula toruloides trans-cinnamate + NH3
-
r
trans-cinnamate + NH3
-
Rhodotorula toruloides L-phenylalanine
-
r

Subunits

Subunits Comment Organism
tetramer
-
Rhodotorula toruloides

Synonyms

Synonyms Comment Organism
PAL
-
Rhodotorula toruloides

General Information

General Information Comment Organism
metabolism key gateway enzyme linking the phenylpropanoid secondary pathway to primary metabolism Rhodotorula toruloides