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Literature summary for 4.3.1.24 extracted from
- Biochemical evaluation of phenylalanine ammonia lyase from endemic plant Cyathobasis fruticulosa (Bunge) Aellen. for the dietary treatment of phenylketonuria (2016), Food Technol. Biotechnol., 54, 296-303 .
Application
| Application | Comment | Organism |
|---|---|---|
| food industry | the enzyme from Cyathobasis fruticulosa is a potential candidate for serial production of dietary food and biotechnological products | Cyathobasis fruticulosa |
| medicine | enzyme substitution therapy with the phenylalanine ammonia lyase is a new approach to the treatment of patients with phenylketonuria | Cyathobasis fruticulosa |
| pharmacology | enzyme substitution therapy with the phenylalanine ammonia lyase is a new approach to the treatment of patients with phenylketonuria | Cyathobasis fruticulosa |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | optimum is 200 mM | Cyathobasis fruticulosa |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine | Cyathobasis fruticulosa | - |
trans-cinnamate + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cyathobasis fruticulosa | - |
Bunge Aellen. | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cyathobasis fruticulosa |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 98.6 | - |
pH 8.8, 37°C | Cyathobasis fruticulosa |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 12 months, about 35% loss of activity | Cyathobasis fruticulosa |
| 23°C, 90% loss of activity after 5 days | Cyathobasis fruticulosa |
| 4°C, 35% loss of activity after 5 days | Cyathobasis fruticulosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine | - |
Cyathobasis fruticulosa | trans-cinnamate + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotetramer | x * 70000 + X * 23000, SDS-PAGE | Cyathobasis fruticulosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAL | - |
Cyathobasis fruticulosa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Cyathobasis fruticulosa |
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Release 2023.1 (January 2023)
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