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Literature summary for 4.3.1.19 extracted from

  • Guo, Y.; Xu, J.; Han, M.; Zhang, W.
    Generation of mutant threonine dehydratase and its effects on isoleucine synthesis in Corynebacterium glutamicum (2015), World J. Microbiol. Biotechnol., 31, 1369-1377 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) Corynebacterium glutamicum

Protein Variants

Protein Variants Comment Organism
F383A the mutant enzyme shows complete resistance to feedback inhibition by isoleucine Corynebacterium glutamicum
V140M the specific activity of V140M mutant enzyme is 1.5fold higher than that of the wild-type enzyme Corynebacterium glutamicum
V140M/F383A the mutant enzyme displays 1.5fold specific activity and complete resistance to isoleucine Corynebacterium glutamicum

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum Q04513
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Corynebacterium glutamicum ATCC 13032 Q04513
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Synonyms

Synonyms Comment Organism
threonine dehydratase
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Corynebacterium glutamicum