BRENDA - Enzyme Database
show all sequences of 4.3.1.17

Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica

Husain, A.; Jeelani, G.; Sato, D.; Ali, V.; Nozaki, T.; Mol. Biochem. Parasitol. 170, 100-104 (2010)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
His-tagged version expressed in Escherichia coli BL21(DE3)
Entamoeba histolytica
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-oxobutyrate
20 mM: 49.3% inhibition, not reversed by 5 mM AMP
Entamoeba histolytica
ATP
-
Entamoeba histolytica
glyoxylate
20 mM: 54.1% inhibition, not reversed by 5 mM AMP
Entamoeba histolytica
L-cysteine
competitive
Entamoeba histolytica
pyruvate
20 mM: 45.3% inhibition, not reversed by 5 mM AMP
Entamoeba histolytica
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
7.3
-
L-threonine
-
Entamoeba histolytica
13.5
-
L-serine
-
Entamoeba histolytica
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
45000
-
x * 45000, calculated
Entamoeba histolytica
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Entamoeba histolytica
B1N2N4
-
-
Purification (Commentary)
Commentary
Organism
immobilized metal ion affinity chromatography (Ni2+)
Entamoeba histolytica
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-serine
-
705606
Entamoeba histolytica
pyruvate + NH3
-
-
-
?
L-threonine
-
705606
Entamoeba histolytica
2-oxobutyrate + NH3
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 45000, calculated
Entamoeba histolytica
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3
-
L-serine
-
Entamoeba histolytica
5.2
-
L-threonine
-
Entamoeba histolytica
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
9
-
Entamoeba histolytica
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Entamoeba histolytica
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.1
-
L-cysteine
substrate L-serine
Entamoeba histolytica
2.2
-
L-cysteine
substrate L-threonine
Entamoeba histolytica
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Entamoeba histolytica
calculated
-
6.68
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
10
-
-
Entamoeba histolytica
ATP
Cloned(Commentary) (protein specific)
Commentary
Organism
His-tagged version expressed in Escherichia coli BL21(DE3)
Entamoeba histolytica
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Entamoeba histolytica
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
10
-
-
Entamoeba histolytica
ATP
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-oxobutyrate
20 mM: 49.3% inhibition, not reversed by 5 mM AMP
Entamoeba histolytica
ATP
-
Entamoeba histolytica
glyoxylate
20 mM: 54.1% inhibition, not reversed by 5 mM AMP
Entamoeba histolytica
L-cysteine
competitive
Entamoeba histolytica
pyruvate
20 mM: 45.3% inhibition, not reversed by 5 mM AMP
Entamoeba histolytica
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.1
-
L-cysteine
substrate L-serine
Entamoeba histolytica
2.2
-
L-cysteine
substrate L-threonine
Entamoeba histolytica
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
7.3
-
L-threonine
-
Entamoeba histolytica
13.5
-
L-serine
-
Entamoeba histolytica
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
45000
-
x * 45000, calculated
Entamoeba histolytica
Purification (Commentary) (protein specific)
Commentary
Organism
immobilized metal ion affinity chromatography (Ni2+)
Entamoeba histolytica
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-serine
-
705606
Entamoeba histolytica
pyruvate + NH3
-
-
-
?
L-threonine
-
705606
Entamoeba histolytica
2-oxobutyrate + NH3
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 45000, calculated
Entamoeba histolytica
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
3
-
L-serine
-
Entamoeba histolytica
5.2
-
L-threonine
-
Entamoeba histolytica
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
9
-
Entamoeba histolytica
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Entamoeba histolytica
calculated
-
6.68
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.2
-
L-serine
-
Entamoeba histolytica
0.7
-
L-threonine
-
Entamoeba histolytica
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.2
-
L-serine
-
Entamoeba histolytica
0.7
-
L-threonine
-
Entamoeba histolytica
Other publictions for EC 4.3.1.17
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746916
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-
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1
1
19
-
-
10
-
-
-
1
-
2
-
-
-
-
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-
1
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11
-
-
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-
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1
-
1
19
-
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-
-
10
-
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-
1
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-
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-
-
1
-
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-
11
-
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-
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-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
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-
1
-
4
1
1
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1
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1
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1
1
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1
1
1
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-
1
-
4
1
1
-
1
-
1
-
1
-
-
-
-
-
-
-
747091
Yan
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-
-
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-
-
2
-
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1
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-
728723
Wang
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25
741-749
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-
-
1
1
2
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
729214
Chen
Allosteric activation and cont ...
Bacillus subtilis, Legionella pneumophila
Biochemistry
51
5320-5328
2012
-
-
2
-
-
-
6
5
-
2
-
-
-
4
-
-
2
-
-
-
-
-
2
-
-
-
-
5
2
2
-
-
-
-
-
-
-
2
-
-
-
-
-
6
-
5
-
2
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
5
2
2
-
-
-
-
-
-
5
5
729219
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Legionella pneumophila
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51
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-
1
-
-
-
-
1
-
-
3
-
-
4
-
-
1
1
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1
2
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-
1
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1
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3
-
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1
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-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713970
Xu
Kinetic, mutagenic, and struct ...
Legionella pneumophila
Arch. Biochem. Biophys.
515
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2011
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1
-
-
8
-
4
6
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
6
2
-
-
-
2
-
-
-
1
-
-
-
8
-
-
4
2
6
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
6
2
-
-
-
-
-
-
-
5
5
729942
Rybniker
The cytotoxic early protein 77 ...
Mycolicibacterium smegmatis
J. Basic Microbiol.
51
515-522
2011
-
-
1
-
-
-
-
1
-
-
2
1
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
1
-
-
1
-
-
-
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-
1
1
-
-
-
-
-
-
1
-
-
2
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
705606
Husain
Characterization of two isotyp ...
Entamoeba histolytica
Mol. Biochem. Parasitol.
170
100-104
2010
-
-
1
-
-
-
5
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
2
1
-
-
1
2
1
1
-
-
1
1
-
-
-
1
5
2
2
-
-
1
-
-
-
-
1
-
-
-
-
2
1
-
-
-
2
1
-
-
1
-
-
-
-
2
2
715372
Zhang
Deficiency in L-serine deamina ...
Escherichia coli
J. Bacteriol.
192
5515-5525
2010
-
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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1
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
691069
Yamada
A catalytic mechanism that exp ...
Homo sapiens
Biochim. Biophys. Acta
1780
809-818
2008
-
-
1
1
5
-
-
-
-
-
-
1
-
3
-
-
1
1
-
2
-
-
2
2
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
5
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
2
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
692849
Risso
Elucidation of an alternate is ...
Geobacter sulfurreducens, Geobacter sulfurreducens DSM 12127
J. Bacteriol.
190
2266-2274
2008
-
-
1
-
-
-
1
-
-
-
-
3
-
2
-
-
-
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-
1
-
6
-
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1
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-
-
1
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3
-
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-
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693834
Zhao
A quantum mechanical/molecular ...
Rattus norvegicus
J. Phys. Chem. B
112
13091-13100
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
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-
1
-
-
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2
-
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1
-
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1
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1
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2
-
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-
-
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-
-
-
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-
-
-
694235
Zhang
Deficiency in L-serine deamina ...
Escherichia coli K-12
Mol. Microbiol.
69
870-881
2008
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
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-
1
-
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1
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1
-
1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678810
Zhong
Excess leucine intake induces ...
Rattus norvegicus
Biosci. Biotechnol. Biochem.
71
2614-2617
2007
1
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
7
-
1
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1
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1
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3
7
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1
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-
680142
Anfora
Roles of serine accumulation a ...
Escherichia coli
Infect. Immun.
75
5298-5304
2007
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
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-
-
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2
-
1
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1
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-
1
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-
2
-
1
-
-
-
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-
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-
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-
677454
Lopez-Flores
Downregulation in the expressi ...
Rattus norvegicus
Am. J. Physiol.
291
R1295-R1302
2006
-
-
-
-
-
-
1
2
-
-
1
1
-
2
-
-
-
-
-
2
2
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
2
2
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
678411
Ogawa
Enzymatic and biochemical prop ...
Homo sapiens
Biochim. Biophys. Acta
1764
961-971
2006
-
-
1
-
4
-
-
12
-
-
2
1
-
3
-
-
1
-
-
4
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
12
-
-
2
1
-
-
-
1
-
4
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
680934
Elzainy
-
Occurrence of L-serine (L-thre ...
Aspergillus niger, Aspergillus niger NRRL 3, Aspergillus terreus, Aspergillus terricola
J. Biol. Sci.
6
564-571
2006
-
-
-
-
-
-
-
2
-
-
-
8
-
5
-
-
3
-
-
-
-
-
8
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
8
-
-
-
3
-
-
-
-
8
-
3
-
-
-
3
-
-
-
-
-
-
-
-
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Bacterial L-serine dehydratase ...
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210774
Farias
-
Evidence for the presence of L ...
Lactobacillus murinus, Lactobacillus murinus CNRZ 313
J. Gen. Appl. Microbiol.
31
563-567
1985
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4
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4
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210798
Ramos
Occurrence of a catabolic L-se ...
Saccharomyces cerevisiae
Eur. J. Biochem.
123
571-576
1982
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1
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210775
Newman
In vitro studies on L-serine d ...
Escherichia coli
Can. J. Biochem.
58
1292-1297
1980
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6
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210776
Yeung
Comparative studies on threoni ...
Rattus norvegicus
Int. J. Biochem.
11
161-164
1980
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210777
Gannon
L-Serine dehydratase from Arth ...
Arthrobacter globiformis
Biochem. J.
161
345-355
1977
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210778
Gannon
An activity stain for L-serine ...
Arthrobacter globiformis
Anal. Biochem.
79
594-596
1977
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5592
Porter
Characterization of human cyst ...
Homo sapiens
Biochim. Biophys. Acta
364
128-139
1974
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210781
Morikawa
-
Purification and some properti ...
Corynebacterium sp.
Agric. Biol. Chem.
38
531-537
1974
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4
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5
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210782
Isenberg
Studies on L-serine deaminase ...
Escherichia coli
J. Bacteriol.
118
53-58
1974
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210783
Simon
-
Interactions of L-serine dehyd ...
Rattus norvegicus
Biochim. Biophys. Acta
334
208-217
1974
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210797
Hopgood
The relative stability of live ...
Rattus norvegicus
Biochem. J.
144
371-376
1974
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210780
Grillo
Serine dehydratase in animal t ...
Gallus gallus, Rattus norvegicus
Acta Vitaminol. Enzymol.
27
51-61
1973
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210784
Simon
L-Serine dehydratase from rat ...
Rattus norvegicus
Biochim. Biophys. Acta
321
361-368
1973
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210785
Hoshino
Influence of monovalent cation ...
Rattus norvegicus
Eur. J. Biochem.
27
388-394
1972
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210786
Sagers
-
L-Serine dehydratase (Clostrid ...
Clostridium acidi-urici
Methods Enzymol.
17B
351-356
1971
1
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210787
Pestana
Inhibition by homocysteine of ...
Rattus norvegicus
Arch. Biochem. Biophys.
146
373-379
1971
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210799
Suda
-
L-Serine dehydratase (rat live ...
Rattus norvegicus
Methods Enzymol.
17B
346-351
1971
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