Literature summary for 4.2.99.24 extracted from

Chen, X.; Hagel, J.M.; Chang, L.; Tucker, J.E.; Shiigi, S.A.; Yelpaala, Y.; Chen, H.Y.; Estrada, R.; Colbeck, J.; Enquist-Newman, M.; Ibanez, A.B.; Cottarel, G.; Vidanes, G.M.; Facchini, P.J.
A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis (2018), Nat. Chem. Biol., 14, 738-743 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Papaver somniferum

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.022	-	salutaridinol 7-O-acetate	allosteric enzyme, Ka value, pH not specified in the publication, temperature not specified in the publication	Papaver somniferum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
40000	-	gel filtration	Papaver somniferum

Organism

Organism	UniProt	Comment	Textmining
Papaver somniferum	A0A2U9GGW3	isoform THS2	-
Papaver somniferum	A0A2U9GHG9	isoform THS1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
latex	-	Papaver somniferum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
salutaridinol 7-O-acetate	-	Papaver somniferum	thebaine + acetate	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 17000, SDS-PAGE	Papaver somniferum

Synonyms

Synonyms	Comment	Organism
THS1	-	Papaver somniferum
THS2	-	Papaver somniferum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Papaver somniferum

General Information

General Information	Comment	Organism
physiological function	suppression of THS transcript abundance causes a substantial reduction in thebaine levels and a significant accumulation of the upstream intermediates salutaridinol and reticuline	Papaver somniferum

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Release 2023.1 (January 2023)