Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isochorismate | Pseudomonas aeruginosa | - |
salicylate + pyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
gene pchB | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
isochorismate = salicylate + pyruvate | reaction mechanism, the IPL reaction is a concerted but asynchronous hydrogen transfer, by a proposed [1,5]-sigmatropic reaction mechanism with a pericyclic transition state, quantum mechanical/molecular-mechanical calculations and simulations, overview | Pseudomonas aeruginosa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isochorismate | - |
Pseudomonas aeruginosa | salicylate + pyruvate | - |
? | |
isochorismate | pericyclic reaction, elimination of pyruvate. The electrostatic field due to PchB at atoms of isochorismate favors the isochorismate to salicylate transition, molecular dynamics simulations, overview | Pseudomonas aeruginosa | salicylate + pyruvate | - |
? | |
additional information | PchB possesses weak chorismate mutase activity as well and is able to catalyze two distinct pericyclic reactions in a single active site. The enzyme tends to bring its non-native substrate in the same conformation as its native substrate | Pseudomonas aeruginosa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IPL | - |
Pseudomonas aeruginosa |
isochorismate pyruvate lyase | - |
Pseudomonas aeruginosa |
PchB | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme physiologically catalyzes the elimination of the enolpyruvyl side chain from isochorismate to make salicylate for incorporation into the siderophore pyochelin | Pseudomonas aeruginosa |